Browsing by Author "Oniha, M. I."

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Biosynthesized and natural chitosan-based nanoparticles for biomedical applications
(Woodhead Publishing Series in Biomaterials, 2025) Ahuekwe, E. F.; Akinhanmi, Fadekemi O.; Akinyemi, O D.; Taiwo, O. S.; Popoola, T. S.; George, D. S.; Aladele, A. K.; Azeta, J.; Oniha, M. I.
Chitin and chitosans, derived from diverse natural sources, are polysaccharides that have numerous uses in the food, biomedicine, water treatment, and pharmaceutical industries. As a result, the USD 6.8 billion chitosan market saw significant expansion in 2019. Their complex biological characteristics and therapeutic potential are methodically examined in this review, which also highlights their noteworthy antibacterial, antioxidant, and antiinflammatory effects. Even with these praiseworthy qualities, regulatory bodies place restrictions on their recognition as medicinal products. Chitosan is also the best option for creating nanoparticles due to its qualities including biocompatibility, biodegradability, and positive surface charge. The exploration of natural sources highlights extraction strategies and reveals source-specific procedures using a variety of spectroscopic and microscopy techniques. Chitosan-based nanoparticles (ChNPs) are particularly effective in the field of biomedical applications; they work well in tissue engineering, gene therapy, and medication delivery. Their adaptability encompasses a range of aspects, such as the delivery of drugs, antibiotics, polyphenols, vaccines, and gene therapy. A thorough examination of the toxicity and biocompatibility of ChNPs is provided in this review, highlighting the effects of deacetylation degree, structural characteristics, molecular weight, cytotoxicity, and cellular uptake. A close examination is given to the factors impeding the application of biomedicine, highlighting the critical need for regulatory frameworks. While chitosan’s symphony of applications reverberates throughout a multitude of biomedical fields, continued research and development endeavors are essential for revolutionizing uses and guaranteeing their prudent integration into a variety of sectors
Chitosan-based nanoformulation of metal and metal oxide nanoparticles
(Woodhead Publishing Series in Biomaterials, 2025) Ahuekwe, E. F.; Aworunse, O. S.; Akinpelu, Sharon O.; Adekeye, B. T.; Abimbola, S.; Akinyemi, O. D.; Aladele, A. K.; Oyesile, O.; Ayomide, A. F.; Oniha, M. I.; Emelike, C. U.
Chitosans are biopolymers of chitin with remarkable properties, including biocompatibility, biodegradability, and antibacterial activity. Chitosanbased nanoparticles are useful vehicles for drug delivery in biomedicine, as they improve precision and reduce side effects in the administration of proteins and peptides, antibiotics, gene therapy, and cancer treatment. Furthermore, chitosan formulations improve the CT and magnetic resonance imaging scans’ sensitivity and precision, which makes tumor identification and diagnosis easier. The regenerative qualities of chitosan are useful in bone tissue engineering, wound healing, and tissue regeneration. Chitosan’s function in nanocatalysis is highlighted by its sustainability and environmental applications. It serves as a long-lasting support for metal catalysts such as gold and palladium, enabling environmentally friendly catalytic applications in a variety of sectors. Chitosan’s antibacterial effectiveness contributes to wastewater treatment, enhancing environmental sustainability. Chitosan-coated seeds and plant protection solutions enhance plant germination, promote plant growth, and provide a sustainable substitute for traditional pesticides in agriculture. Obstacles and prospects refinement of chitosan derivatives and nanoparticles are required to improve safety and lessen toxicity concerns. Sustainable and cost-effective synthesis techniques are essential for mass manufacturing and market penetration. Literature advises more research to fully maximize chitosan benefits in a variety of industries, such as food packaging, cosmetics, and sophisticated materials. Overall, the adaptability of chitosan nanoparticles underscores its potential for an array of industrial applications, healthcare, and environmental protection, leading to industrial transformations that support a sustainable future.
Environmental Impact of Pre-occupational radon level measurements in medical imaging facilities of a tertiary hospital in south-west Nigeria
(ICSAEES-2024, Lagos, Nigeria, 2024) Aremu, A. A.; Oni, O. M.; Oladipo, A. E.; Oladapo, O. O.; Obafemi, Y. D.; Oniha, M. I.; Babarimisa, I. O.; James, U. E.
Radiation facilities are placed in an enclosed environment to prevent scattered radiation from getting out of the room, by so doing the rooms foil gas exchange from the outdoor environment, thereby increasing the radon concentration in the indoor air. This study aimed at estimating the occupational radon exposure level in medical facility room in order to estimate the radiological risk in such environment. RAD7 electronic device was used to measure theindoor radon concentration in the five proposed roomsin the newly built Radiology department of a University Teaching Hospital while a digital thermometer was used to measure the ambient temperature. The radon concentrations ranged between 12.09Bq/m3and 58.52 Bq/m3. The ultrasound room has the least average value of 12.09 Bqm-3 and the Fluoroscopy room has the maximum average value of 58.52 Bqm-3. The radon level translated into the effective dose, working level and excess life-time cancer risk for any worker staying for a period of nine hours per day, over a year. Fluoroscopy facility was estimated to present the highest annual absorbed dose and annual effective dose with 0.73 mSvy-1 and 0.8858 mSv y-1, respectively.The mean radon concentration for the five rooms was 41.96Bq/m3. The calculated annual effective dose rate and the mean annual absorbed dose rate to the lung within the radiation facilities rooms were 0.529 mSvy- 1and 0.6350 mSv y-1, respectively.The indoor radon concentrations measured and the effective dose value of 200 Bq/m3 and 1 mSvy-1 respectively is below the reference limitset by International Commission Radiation Protection (ICRP) Agency.This implies that the radiation facility rooms are in conformity with international best practices and this is in agreement with SDG 3 (Good Health and well –being)
In vivo Evaluation of Plant Extracts against Common Phytopathogenic Fungi Isolated from Pawpaw (Carica papaya L.)
(IOP Conf. Series: Earth and Environmental Science, 2025) Oniha, M. I.; Eni, A. O.; Akinnola, Olayemi O.; Omonigbehin, E. A.; Adegboye, B. E.; Taiwo, O. S.; Odetunmibi, O.A.; Oyejide, S.O.; Aina, M.O.; Isibor, P. O.; Ahuekwe, E.F.
Plants possess various efficacious natural products to curtailing various problems associated with man and his environment. Fungi cause significant postharvest losses to global pawpaw (Carica papaya) production, particularly in Africa. Current control methods focus primarily on synthetic fungicides that are hazardous to the environment, while plant-based fungicides are characterised with biofriendly and costeffective potential. In this study, three plant extracts were investigated for their in vivo antifungal property opposed to three phytopathogenic mycoflora isolated from Carica papaya post harvest. Aqueous extracts of Moringa oleifera, Telfaira occidentalis and Bauhinia monandra leaves were evaluated at aaglomerations of 150 mg/ml and 75 mg/ml for their antifungal properties in papaya fruits for 7 days. In vivo antifungal evaluation revealed that the three plant extracts showed varying degrees of inhibitory activity against Aspergillus niger, Aspergillus flavus and Rhizopus oryzae. Of the three evaluated plants, B. monandra showed higher antifungal activity during the post-inoculation period. The concentration of 150 mg/ml of aqueous extracts of the plants preserved the fruits and inhibited fungal growth in a range of 3-5 days, while the 75mg/ml concentration of Moringa oleifera, Telfiaria occidentalis and Bauhinia monandria inhibited fungal growth for 3, 2 and 3 days after inoculation, respectively. Significant weight loss was observed in fruits inoculated for both treatments and controls at both concentrations (p-value <0.05). This experimentation has ssubstantiated that the aqueous leaf extracts of M. oleifera, T. occidentalis, and B. monandra possess the potential as natural antifungals for the control and management of fungal diseases