Department of Biochemistry

Permanent URI for this communityhttp://itsupport.cu.edu.ng:4000/handle/123456789/28750

Welcome to the Department of Biochemistry

Browse

Filters

20251

Settings

Author: search.filters.author.ALEEM, Adeola Abibat

Search Results

Now showing 1 - 1 of 1
  • No Thumbnail Available
    Item
    ASSOCIATION OF IL6, TNF-α and IL10 POLYMORPHISM WITH PROSTATE CANCER RISK AND SEVERITY IN NIGERIAN MEN
    (Covenant University Ota, 2025-09) ALEEM, Adeola Abibat; Covenant University Dissertation
    One of the critical health burdens in Nigeria is prostate cancer (PCa) with high risk and death, especially men of African indigene. Persistent inflammation is influenced by soluble molecules such as interleukin-6 (IL6), tumor necrosis factor-alpha (TNFα), and interleukin-10 (IL10), which influences PCa development and malignancy, with single nucleotide polymorphisms (SNPs) in these genes influencing disease susceptibility and severity. This study investigated the association of IL6 (rs1800795), TNFα (rs1800629), and IL10 (rs1800872) SNPs with PCa risk and severity in a Nigerian cohort comprising 75 PCa victims and 81 healthy controls. Genotype and allele frequencies were determined using TaqMan SNP genotyping, and associations with PCa risk and severity (assessed via Gleason scores) were analysed. The results showed no statistical relationship between the studied SNPs and PCa risk. Specifically, rs1800629 showed a predominance of the GG genotype (85.7% cases, 86.4% controls) with a low minor allele frequency (MAF) for the A allele (7.04% cases, 6.72% controls; OR = 0.96, 95% CI: 0.39–2.38, p = 0.930), and no correlation with Gleason scores (p = 0.58). For rs1800872, genotype frequencies (TT: 14.3% cases, 16.9% controls; TG: 50.0% cases, 58.4% controls; GG: 35.7% cases, 24.7% controls). The minor T allele was less frequent in cases (39.3%) than in controls (46.1%), suggesting a protective effect, though the difference is not statistically significant. No meaningful associations was observed with PCa risk and the genotypes (OR = 1.711, GG vs. TT, p = 0.301; OR = 1.017, TG vs. TT, p = 0.971) or with Gleason scores (p = 0.95). Notably, rs1800795 exhibited complete monomorphism (GG genotype in all subjects), precluding its analysis as a biomarker for PCa risk or severity. The lack of significant associations may be attributed to population-specific genetic profiles, particularly the monomorphism of rs1800795 and low MAF of rs1800629, as well as the limited sample size, which constrained statistical power. These findings show the importance of population-specific genetic studies, as allele frequencies and their disease associations vary across populations. Future research should involve larger cohorts, genome-wide association studies, and functional analyses to explore other IL-6 SNPs, gene-environment interactions, and novel PCa-associated variants in Nigerians, contributing to improved molecular epidemiology and potential biomarkers for early diagnosis and targeted therapies in African populations.