Effects of Fibre-Enriched Diets on Tissue Lipid Profiles of MSG Obese Rats
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Elsevier Ltd. All rights reserved
Abstract
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In order to investigate the influence of some fibre-enriched diets on tissue lipids in an animal model of
obesity induced by the administration of monosodium glutamate (MSG), obese rats were fed diets containing
30% of Acha, Cassava, Maize and Plantain for five weeks and weight gain, feed intake and lee index
were recorded. The lipid profiles of plasma, erythrocytes, kidney, heart and liver as well as hepatic 3-
hydroxyl-3-methylglutaryl-CoA (HMG-CoA) reductase activity were measured. The diets significantly
(p < 0.05) reduced weight gain and lee index in the obese rats. Obesity-induced increase in plasma and
erythrocytes lipid levels was significantly (p < 0.05) reduced by these diets. MSG-induced obesity also
resulted in a significant increase (p < 0.05) in hepatic cholesterol level which was reduced by the diets.
MSG-obesity was characterised by a significant (p < 0.05) increase in cholesterol, triacylglycerol and
phospholipids in kidney and this was reversed by the diets except Maize which did not reverse the
increased cholesterol level. Only Acha reversed the obesity-induced increase in heart cholesterol and
phospholipids. The increased activity of hepatic HMG-CoA reductase associated with obesity was also significantly
(p < 0.05) reduced by the diets. In conclusion, dyslipidemia associated with MSG-induced obesity
could be attenuated by consumption of fibre-enriched diets
Keywords
QD Chemistry, QH301 Biology