Effects of Fibre-Enriched Diets on Tissue Lipid Profiles of MSG Obese Rats

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dc.creatorRotimi, Oluwakemi A, Olayiwola, I.O., Ademuyiwa, Oladipo, Balogun, Elizabeth A.
dc.date2012
dc.date.accessioned2025-03-27T15:44:46Z
dc.descriptionIn order to investigate the influence of some fibre-enriched diets on tissue lipids in an animal model of obesity induced by the administration of monosodium glutamate (MSG), obese rats were fed diets containing 30% of Acha, Cassava, Maize and Plantain for five weeks and weight gain, feed intake and lee index were recorded. The lipid profiles of plasma, erythrocytes, kidney, heart and liver as well as hepatic 3- hydroxyl-3-methylglutaryl-CoA (HMG-CoA) reductase activity were measured. The diets significantly (p < 0.05) reduced weight gain and lee index in the obese rats. Obesity-induced increase in plasma and erythrocytes lipid levels was significantly (p < 0.05) reduced by these diets. MSG-induced obesity also resulted in a significant increase (p < 0.05) in hepatic cholesterol level which was reduced by the diets. MSG-obesity was characterised by a significant (p < 0.05) increase in cholesterol, triacylglycerol and phospholipids in kidney and this was reversed by the diets except Maize which did not reverse the increased cholesterol level. Only Acha reversed the obesity-induced increase in heart cholesterol and phospholipids. The increased activity of hepatic HMG-CoA reductase associated with obesity was also significantly (p < 0.05) reduced by the diets. In conclusion, dyslipidemia associated with MSG-induced obesity could be attenuated by consumption of fibre-enriched diets
dc.formatapplication/pdf
dc.identifierhttp://eprints.covenantuniversity.edu.ng/3450/
dc.identifier.urihttps://repository.covenantuniversity.edu.ng/handle/123456789/32429
dc.languageen
dc.publisherElsevier Ltd. All rights reserved
dc.subjectQD Chemistry, QH301 Biology
dc.titleEffects of Fibre-Enriched Diets on Tissue Lipid Profiles of MSG Obese Rats
dc.typeArticle

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