Polygenic Risk Score in Africa Population: Progress and challenges
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Description
Polygenic risk score (PRS) analysis is a powerful method been used to estimate an
individual's genetic risk towards targeted traits. PRS analysis could be used to obtain
evidence of a genetic effect beyond Genome-Wide Association Studies (GWAS) results
i.e. when there are no significant markers. PRS analysis has been widely applied to
investigate the genetic basis of several traits including rare diseases. However, the
accuracy of PRS analysis depends on the genomic data of the underlying population. For
instance, several studies showed that obtaining higher prediction power of PRS analysis
is challenging for non-Europeans. In this manuscript, we reviewed the conventional PRS
methods and their application to sub-saharan Africa communities. We concluded that
the limiting factor of applying PRS analysis to sub-saharan populations is the lack of
sufficient GWAS data. Also, we recommended developing African-specific PRS tools.
Keywords
QA Mathematics, QA75 Electronic computers. Computer science