2025-04-01https://repository.covenantuniversity.edu.ng/handle/123456789/40853Antioxidant effects of ethanolic extract of Caesalpinia bonduc and its isolated bioactive compounds were evaluated in vitro. The compounds included two new cassane diterpenes, 1α,7α-diacetoxy-5α,6β-dihydroxyl-cass-14(15)-epoxy-16,12-olide (1) and 12α-ethoxyl-1α,14β-diacetoxy-2α,5α-dihydroxyl-cass-13(15)-en-16,12-olide (2); and others, bonducellin (3), 7,4’-dihydroxy-3,11-dehydrohomoisoflavanone blocking the expression of SREBP-1c and FAS through LKB1/SIRT1 and AMPK activation in HepG2 cells, suggesting that CDCQ is a novel AMPK activator with a potential role in the prevention obesity.application/pdfQD Chemistry, QH301 BiologyConference or Workshop Item