DSpace 8

DSpace is the world leading open source repository platform that enables organisations to:

  • easily ingest documents, audio, video, datasets and their corresponding Dublin Core metadata
  • open up this content to local and global audiences, thanks to the OAI-PMH interface and Google Scholar optimizations
  • issue permanent urls and trustworthy identifiers, including optional integrations with handle.net and DataCite DOI

Join an international community of leading institutions using DSpace.

The test user accounts below have their password set to the name of this software in lowercase.

  • Demo Site Administrator = dspacedemo+admin@gmail.com
  • Demo Community Administrator = dspacedemo+commadmin@gmail.com
  • Demo Collection Administrator = dspacedemo+colladmin@gmail.com
  • Demo Submitter = dspacedemo+submit@gmail.com
Photo by @inspiredimages
 

Communities in DSpace

Select a community to browse its collections.

Now showing 1 - 5 of 9

Recent Submissions

No Thumbnail Available
Item
Plasmodium falciparum Transketolase as a Drug Target in Malaria: A Review of Current Research and Future Perspectives
(Journal of Science and Technology, Research Vol. 7, Special Issue: Landmark University International Conference, 2025) Orogun, Yetunde; Fadare, Olatomide; Bajepade, Tobilola; Raimi, Olawale; Ogunlana, Olubanke
Malaria is a severe infectious disease caused by Plasmodium species, primarily Plasmodium falciparum, which accounts for the most deaths globally. Africa bears the heaviest malaria burden, with countries like Nigeria, Congo, and Mozambique contributing to a significant percentage of global cases. It is transmitted through the bite of an infected female Anopheles mosquito. The fight against malaria has been challenged by the emergence of resistance to most antimalarial drugs, including Artemisinin-based Combination Therapies (ACTs). This highlights the urgent need for novel drug targets. Transketolase (Tk), a key enzyme in the pentose phosphate pathway (PPP) non-oxidative branch, plays a vital role in cellular metabolism and has been identified to support parasite survival. Plasmodium falciparum transketolase (PfTk) has been identified as an emerging drug target due to its essential role in the parasite's metabolism and low structural homology with human transketolase (HTk). This review aims to provide an overview of PfTk as a potential anti-malarial drug target and to highlight the key research direction for future drug development. It examines the current research on PfTk as a therapeutic target, focusing on its biochemical properties, structural and functional characteristics, and potential inhibitors' development as a therapeutic strategy while exploring future perspectives.
No Thumbnail Available
Item
Leiomyomas: A Review on its Relationships with Transforming Growth Factor–βeta
(Journal of Science and Technology, Research Vol. 7, 2025) Okesola, Mary A.; Familua, Olufemi M.; Nwonuma, Charles O.; Adebiyi, Marion O.; Ogunlana, Olubanke O.; Osemwegie, Omorefosa O.
This study investigates the Transforming Growth Factor- Beta (TGF-β)'s role in leiomyoma development. Leiomyomas remain the most common benign tumor traumatizing women especially Black women at the attainment of reproductive age. Reproductive hormones, age, diet lack of vitamin D, are some of the implicated risk factors. However, TGF-β have not been investigated in our population. Different search engines were utilized to obtain articles on the impact of TGF-β and leiomyomas development published in English from 2009 to 2024 by using search identifier keys like leiomyomas, growth genes, TGF-β, uterine fibroid, myomas, and growth factors. Furthermore, indicated articles' reference were checked lists to find further pertinent works on the TGF-β in fibroid development. TGF-β is a cytokine that regulates numerous cell processes including cell differentiation, migration, apoptosis, and cell proliferation are regulated by TGF-β. However, there were inconsistency in the literatures concerning the impact of this growth gene in leiomyomas development thereby creating a gap in knowledge on the impact of this growth gene (TGF-β) in leiomyomas development. Hence, the synthesis of this review's is to advance our understanding on the influence of transforming growth factor Beta in the genesis of uterine fibroid.
No Thumbnail Available
Item
Evaluation of Analgesic Property of Silver Nanoparticles Synthesized Using Mitracarpus scaber Aqueous Extract
(Materials Science Forum (Volume 1148), 2025-05) Adesipe, Temitayo; Iweala, Emeka E.J.; Adebayo, Abiodun H.
Pain is one of the main causes for which people seek medical attention. Strong, long-lasting, safe analgesics are therefore still needed in the medical industry to treat a wide range of painful disorders, despite recent advancements in pain treatment. The current work is intended to assess the analgesic properties of silver nanoparticles (AgNPs) synthesized using Mitracarpus scaber aqueous extract. Aqueous extraction of Mitracarpus scaber whole plant was done and employed to make and cap AgNPs using 0.1M AgNO3 solution. The produced AgNPs were examined using a variety of methods, such as Fourier Transform Infrared Spectroscopy (FTIR), UV VIS, and Transmission Electron Microscopy (TEM). Acetic acid writhing and hot plate tests were then used to investigate the analgesic activity of various doses of the biosynthesized AgNPs. AgNPs production was detected by UV-vis spectroscopy at λ max = 425 nm. The biosynthesized AgNPs had a size range of 4-5 nm, were crystalline and spherical in shape, according to TEM investigations. FTIR analysis on the other hand revealed the involvement of phenyl, hydroxyl, carbonyl, and aliphatic carbon-hydrogen bonds in the AgNPs' production. The biogenic silver nanoparticles showed the highest reduction of writhes and pain at the doses of 100 and 50 mg/kg b.w. respectively, which were significantly higher than the analgesic activity elicited by Diclofenac (50 mg/kg b.w.) for both assays. The present work therefore concludes that biogenic silver
No Thumbnail Available
Item
Estimation of Reducing Sugars Released from Solvent-Treated Green Amaranth and Jute Sticks.
(Tropical Journal of Natural Product Research, 2025, Vol 9, 2025) Fashola, Folake A.; Magaji, Bello M; Adebayo, Abiodun H.; Chinedu, Shalom N.
The sticks generated from the highly consumed green amaranth and jute plants in South West Nigeria contain trapped polysaccharide resources that can serve as a source of reducing sugars required in the production of enzymes or biofuel. These waste resources can be harnessed as resources with no food value. To estimate the reducing sugars released from the green amaranth and jute sticks, this study employed four solvents (sodium hydroxide, ethanol, hydrogen peroxide and citrate-phosphate buffer) to harness the trapped sugar resources. The sticks were collected and processed. The components of the processed green amaranth and jute sticks were ascertained by proximate analysis. Interaction effects of solvents, time and temperature on the release of reducing sugars from the processed samples were estimated using the Box-Behnken design and the two-level factorial design. Despite the low protein, fat and moisture content, oven-dried samples showed a higher carbohydrate content. The Box-Behnken design revealed the released reducing sugars using 1.25N sodium hydroxide (2.393 mg/ml ± 0.494), 1.25N hydrogen peroxide (1.240 mg/ml ± 0.093) at 50 °C and 2N ethanol (1.780 mg/ml ± 0.008) at 28 °C for 60 minutes favour oven-dried green stick wastes (OGSW) over oven-dried jute stick wastes (OJSW) by a difference of 61.92%, 73.28% and 31.92%. The ability of citrate-phosphate buffer to release reducing sugars favours OGSW over OJSW with a difference of 37.3% at the factor level of pH 6, 50 °C, and 60 minutes. With the significant interaction effect of variables, the citrate-phosphate buffer was considered a greener and more suitable option.
No Thumbnail Available
Item
Assessment of Extract from Glucose Oxidase-Cellulase Treated Jute Sticks and Green Amaranth Sticks for the Production of Lignocellulose-Based Bioethanol.
(Tropical Journal of Natural Product Research, 2025, Vol 9, 2025) Fashola, Folake A.; Ibidapo, Olubunmi I; Adaran, Adekunle S; Adebayo, Abiodun H.; Chinedu, Shalom N.
The possibility that some carbohydrate oxidases are capable of catalytically cleaving glycosidic bonds offers the opportunity for glucose oxidase to achieve the depolymerization of agro wastes required in the production of second-generation bioethanol. The present study aimed to ascertain the effect of glucose oxidase and cellulase isolated from Aspergillus sp. on locally sourced jute sticks and green amaranth sticks for the production of bioethanol. The Box Behnken design was employed to assess the effect of the different concentrations of sucrose, waste extracts and pH on fermentation efficiency, ethanol percent yield, and reducing sugar yield. The selected agro wastes were subjected to fiber detergent analysis, ATR-FTIR, XRD, and SEM. The fermentation broth was subjected to ATR-FTIR analysis. Compared to oven-dried jute extract, the maximum ethanol yield was achieved at 72 hours for 50% broth containing oven-dried green amaranth extract by a difference of 65.6%. Optimization using the Box Behnken design resulted in an increased yield of ethanol (198%), fermentation efficiency (3.86%) and reducing sugar yield (27.97%) at the combination of factor levels of 5% (sucrose concentration), 2.5% (oven-dried green amaranth extract concentration) and pH 4.5. The cleaving of glycosidic bonds in the waste samples was revealed by ATR-FTIR and further confirmed by SEM. With the evidence of the characteristic bands associated with the presence of ethanol in the fermentation broth, it was concluded that the inclusion of glucose oxidase at low concentrations in the presence of cellulase supported the release of reducing sugars required for the production of lignocellulose - based bioethanol.