Browsing by Author "Ajani, O. O."
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Item Application of VLF-EM response and geoelectrical sounding in groundwater investigation around an active dumpsite(Application of VLF-EM response and geoelectrical sounding in groundwater investigation around an active dumpsite, 2024) Adeniji, A. A.; Ajani, O. O.; Adagunodo, T. A.An integrated geophysical method combining very low frequency electromagnetic (VLF-EM) and vertical electrical sounding (VES) methods were carried out around Adaland, Southwestern Nigeria, located within latitude 70 54' 0" and longitude 40 43' 0", with a view to investigate the possible impact of dumpsite on groundwater.This is the major study in the environment to offer extensive evidence regarding the suitability of obtaining quality groundwater. In this research, eight VLF-EM and twelve VES data sets were generated, which were then used to estimate the linear structure, bedrock formation, subsurface geological characteristics, and identification of leachate pathways. The VLF-EM data were analyzed by employing Karous_Hjelt and Microsoft Excel, while the VES data were investigated using the WinRESIST software. TheVLF-EM results confirmed the presence of conductive zones, which might be due to fracture, fault and contact zones or weathered basements. The lithological units acquired from the electrical resistivity results revealed four geoelectrical layers such as topsoil, weathered-based, fractured basement and fresh basement. However, the identified weathered layers and fractured basements from the geoelectrical sections and the corresponding Karous and Hjelt (K-H) pseudo sectionresults around the dumpsite, constitute the main passages for the possible impact of the open dumpsite on groundwater quality, since leachates from the dumpsite could slowly percolate downwards from the topsoil to the water table. Therefore, the impact of the dumpsite on the groundwater is caused by the inadequate clay materials, near-surface features such as fractures/faults, and lateral in-homogeneity. Thus, integrating both methods has been recommended in site characterization for accessing quality groundwater around a dumpsite environment.Item Functionalized 1,4-Benzothiazine: A Versatile Scaffold with Diverse Biological Properties(John Wiley) Ajani, O. O.Item INVESTIGATION OF LEACHATE INFILTRATION ON GROUNDWATER USING GEO RESISTIVITY AND NATURAL ELECTRIC FIELD METHOD AROUND OJOOU-OLAYANJU’S DUMPSITE, ADA, SOUTHWESTERN NIGERIA(Nigerian Journal of Technology (NIJOTECH) Vol. 43, No. 1,, 2024) Adeniji, A. A.; Ajani, O. O.; Adagunodo. T. A.; Kolawole, T.The investigation of groundwater within the dumpsite environment is highly important in geophysical study. This is because the extent of interaction between the aquiferous medium and the contaminated zone could pose a serious threat to the end users especially humans when consumed. This research aimed at investigating leachate infiltration and its potential influence on groundwater at Ojoou Olayanju's Dumpsite using combining geo-resistivity and natural electric field (NEF) methods. In this study, five dipole-dipole and five NEF measurements were obtained using the Omega resistivity meters and PQWT-150 equipment respectively. The dipole-dipole method was deployed to obtain a 2D near-surface pseudo-section, and the NEF method was used to obtain the frequency curve and profile maps of electric potential difference. The dipole dipole results revealed the lateral variation in the resistivity along the traverses, suggesting that the materials within this near-surface are heterogeneous, and the closely spaced contours' varying gradients indicate fracture, which would facilitate potential leachate filtration. The NEF results revealed curves, and a subsurface image with respect to depth and profile distance. The points of convergence signals on the frequency model correspond to a medium with low resistivity on the profile map. The conductive medium is seen as being saturated with leachate, which suggests that very large portion of the study area around the dumpsite has been contaminated by leachate. Conclusively, it was revealed that leachate filtration is evidence especially at the topsoil and due to the presence of fractured zones, the groundwater quality is at risk of contamination by continuous filtration of leachate.Item Structure-based Design of Coumarin Moieties as Sustainable Inhibitors of Diabetes Mellitus Type 2(2025) Opebiyi, O. T.; Oduselu, G.O.; Ogunnupebi, T. A.; Elebiju, O. F.; Adekoya, Joseph Adeyemi; Ajani, O. O.The search for novel and more potent antidiabetic agents globally is due to the increase in insulin resistance, and more type 2 diabetes patients become susceptible to secondary compilations. Many pharmacologically active compounds are organic, mostly heterocyclic compounds, accounting for about 85% of Food and Drug Administration (FDA)-approved drugs. An example of a heterocyclic compound is coumarin, a benzopyrone group containing oxygen heteroatoms. Coumarin has been reported to possess several pharmacological properties, and combining coumarin with other compounds has made coumarin more potent. Computer-aided techniques have helped improve the design of potential drug candidates. Using computer-aided techniques, coumarin moieties were investigated for antidiabetic activities for future drug design. Coumarin template was used to search for ligand library on PubChem, an open chemistry database at the National Institutes of Health (NIH); 1653 compounds were downloaded with acarbose and metformin in SDF format, 1632 compounds, acarbose and metformin were successfully prepared, and then docked against human pancreatic alpha-amylase (Protein Data Bank- PDB ID: 4GQR) with Autodock vina. The qualitative structural assessment of the best hits from this molecular docking of a ligand library, acarbose and metformin was done. The functional groups present in this best hits, acarbose and metformin were used to generate 15 novel coumarin derivatives. The designed compounds were also docked against 4GQR, and their chemical absorption, distribution, metabolism, excretion, and toxicity (ADMET) studies were conducted. It was observed that 11 of the designed compounds had the lowest binding affinity than the co-crystalized ligand of 4GQR. The best hits compounds from the docking studies were 2g, 2f, 1a and 3e, and the ADMET studies predicted that compounds 1a, 3b, 3c and 3a had better pharmacokinetic and toxicity profiles. This promising result suggests that the designed compounds, particularly 1a, 3b, 3c and 3a, have the potential to be further optimized, synthesized and developed as potent antidiabetic agents, offering a hopeful future for diabetes treatment.Item Synthesis of New N,N-Disubstituted Aryl- and Alkylaryl Sulphonamides and Their Antimicrobial Properties(LAP LAMBERT Academic Publishing) Ajani, O. O.