Department of Biological Sciences

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Author: search.filters.author.Ayanda, Opeyemi I.Start date: 2025

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    The Importance of Murine Models in Determining In Vivo Pharmacokinetics, Safety, and Efficacy in Antimalarial Drug Discovery
    (Pharmaceuticals (MDPI), 2025-03-18) Adebayo, Glory; Ayanda, Opeyemi I.; Rottmann, Matthias
    New chemical entities are constantly being investigated towards antimalarial drug discovery, and they require animal models for toxicity and efficacy testing. Murine models show physiological similarities to humans and are therefore indispensable in the search for novel antimalarial drugs. They provide a preclinical basis (following in vitro assessments of newly identified lead compounds) for further assessment in the drug development pipeline. Specific mouse strains, non-humanized and humanized, have successfully been infected with rodent Plasmodium species and the human Plasmodium species, respectively. Infected mice provide a platform for the assessment of treatment options being sought. In vivo pharmacokinetic evaluations are necessary when determining the fate of potential antimalarials in addition to the efficacy assessment of these chemical entities. This review describes the role of murine models in the drug development pipeline. It also explains some in vivo pharmacokinetic, safety, and efficacy parameters necessary for making appropriate choices of lead compounds in antimalarial drug discovery. Despite the advantages of murine models in antimalarial drug discovery, certain limitations are also highlighted.
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    Potential impacts of microplastic ingestion: Oxidative stress level in commercial fish from the Lagos Lagoon, Nigeria
    (Preprints, 2025) Akinhanmi, Fadekemi O.; Ayanda, Opeyemi I.; Dedeke, Gabriel A.
    The presence of microplastics (MPs) in aquatic systems and the tissues of commercially available fish species poses risks and potential impacts on human health. While MPs have been reported in the surface water, benthic sediment, and edible fish species in the Lagos Lagoon, the possible effects of these contaminants on fish species have been lacking. This study aimed at providing vital information on MP contamination in the Lagos lagoon and highlighting the probable effects on the visceral organs of four fish species, Tilapia (Orechromis niloticus, n=16), Silver catfish (Chrysichthys nigrodigitatus, n=16), African knifefish (Gymnarchus niloticus, n=16) and African catfish (Clarias gariepinus, n=16). Gill, stomach, and liver of the sample specimen were examined for MP contamination and oxidative stress. MP accumulation in all the fish species differed but was detected in all tissues. The most abundant MP type was fibers (64%), followed by fragments (24%). Polyethylene, polychloroprene, polypropylene, and polystyrene were detected by Fourier transform infrared spectroscopy. Oxidative stress analysis of the fish tissues revealed significantly high antioxidant activities (p ≤ 0.05) and lipid peroxidation levels in the microplastic-contaminated tissues. Although this study highlights the possible effects of microplastics on wild fish species, extensive research is necessary to elucidate the cause-effect relationship of environmentally relevant microplastics on fish tissues to conduct as well as report associated risk assessments
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    The Importance of Murine Models and Their Resultant In Vivo Pharmacokinetics, Safety, and Efficacy Assessments for Antimalarial Drug Discovery
    (Preprints, 2026) Adebayo, Glory; Ayanda, Opeyemi I.; Rottmann, Matthias; Ajibaye, Olusola; Oduselu, Gbolahan; Mulindwa, Julius; Ajani, Olayinka O.; Aina, Oluwagbemig; Mäser, Pascal; Adebiyi, Ezekiel
    New chemical entities are consistently being investigated in antimalarial drug discovery and they require animal models for toxicity and efficacy testing. Murine models in searching for novel antimalarial drugs are inevitable because they show unique similarities to human physiology during malaria pathogenesis. Therefore, they provide a preclinical basis (following in vitro assessments of newly identified lead compounds) for further assessment in the drug development pipeline. Specific mouse strains, non-humanized and humanized, have successfully been infected with rodent Plasmodium species and the human Plasmodium falciparum respectively. Infected mice provide a platform for the assessment of treatment options being sought. In vivo pharmacokinetic evaluations are necessary when determining the fate of new lead compounds in addition to the efficacy assessment of these chemical entities. This review highlights specific murine models important for antimalarial drug discovery and their resultant critical in vivo pharmacokinetic, safety, and efficacy assessments necessary for making appropriate choices of lead compounds
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    The Importance of Murine Models in Determining In Vivo Pharmacokinetics, Safety, and Efficacy in Antimalarial Drug Discovery
    (Pharmaceuticals (MDPI), 2025) Adebayo, Glory; Ayanda, Opeyemi I.; Rottmann, Matthias; Ajibaye, Olusola S.; Oduselu, Gbolahan; Oduselu, Gbolahan; Mulindwa, Julius; Ajani, Olayinka O.; Aina, Oluwagbemiga; Mäser, Pascal; Adebiyi, Ezekiel
    New chemical entities are constantly being investigated towards antimalarial drug discovery, and they require animal models for toxicity and efficacy testing. Murine models show physiological similarities to humans and are therefore indispensable in the search for novel antimalarial drugs. They provide a preclinical basis (following in vitro assessments of newly identified lead compounds) for further assessment in the drug development pipeline. Specific mouse strains, non-humanized and humanized, have successfully been infected with rodent Plasmodium species and the human Plasmodium species, respectively. Infected mice provide a platform for the assessment of treatment options being sought. In vivo pharmacokinetic evaluations are necessary when determining the fate of potential antimalarials in addition to the efficacy assessment of these chemical entities. This review describes the role of murine models in the drug development pipeline. It also explains some in vivo pharmacokinetic, safety, and efficacy parameters necessary for making appropriate choices of lead compounds in antimalarial drug discovery. Despite the advantages of murine models in antimalarial drug discovery, certain limitations are also highlighted.
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    Marine Greens as Nutritious Healthy Foods
    (2025) Akinhanmi, Fadekemi O.; Aworunse, Oluwadurotimi S.; Ayanda, Opeyemi I.; Agiriga, Emmanuel