Synthesis of (E) -N'-(5-bromo 2-hydroxybenzylidene)nicotinohydrazide) and its Pt(II), Zn(II), Mn(II), Ni(II) and Mo(V) Complexes as potential Anti-tubercular agent
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SENRA Academic Pblishers
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The cold condensation reaction of nicotinic acid hydrazide and 5-bromo-2-hydroxybenzaldehyde to form a tridentate Schiff base hydrazone ligand, (H2L3) was studied. The prepared ligand was characterized using CHN analyzer, ESI mass spectrometery, IR, 1H NMR,13C NMR, and 2D NMR such as COSY and HSQC. Therafter, five novel complexes [Pt(II), Zn(II), Mn(II), Ni(II) and Mo(V) of the hydrazone ligand were synthesized and characterized based on conductivity measurements,CHN analysis, AAS, magnetic measurement, UV/Vis, IR, ESR and TGA/DTA study. The proposed structures of the metal complexes were further supported through the use of powder X-ray analysis. The tubercular activity study of the compounds was evaluated against Mycobacterium tuberculosis, H37Rv by using micro- diluted method. The study revealed that H2L3 exhibited promising anti-tubercular activity with MIC value of 0.82 µg/mL. Also, metal complexes (Pt(H2L3)Cl)- 0.88 µg/mL, [Mn(H2L3)(CH3COO)2]-0.78 µg/mL, [Zn[H2L3)(CH3COO)2H2O]-0.62 µg/mL and [Ni(H2L3)Cl2]H2O-1.19 µg/mL exhibited significant inhibition as compared to the standard drug (isoniazid-0.91 µg/mL). Complexes 2 and 3 with coordinated acetates showed two-folds inhibition than standard isoniazid drug. However, complex 5 with coordinated chlorine atom displayed lower inhibition when compared to isoniazid.
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QD Chemistry