Hepatotoxicity of dimethylnitrosamine in cats and lizards

dc.creator	Maduagwu, E. N., Anosa, Victor O.
dc.date	1981
dc.date.accessioned	2025-03-29T19:11:50Z
dc.description	The hepatotoxic effects of the oral administration of a single dose of 50 mg dimethylnitrosamine DMN)kg and daily doses of 5 mg and 1mgkg, respectively, to cats and lizards were studied by light microscopy. Centrilobular necrosis was the main alteration detected in the liver of cats as in other animal species studied. The lizards, however, appeared unaffected. Morphological changes observed in the liver of these reptiles included haemorrhage, vacuolation of hepatocytes and diffuse nuclear changes; including pyknosis, karyorrhexis and karyolysis. Haemorrhage was also evident in the liver of cats as well as leukocytic infiltration; including macrophages, lymphocytes and neutrophils. Cats appeared to be more susceptible to DMN poisoning
dc.format	application/pdf
dc.identifier	http://eprints.covenantuniversity.edu.ng/8024/
dc.identifier.uri	https://repository.covenantuniversity.edu.ng/handle/123456789/37409
dc.language	en
dc.publisher	Elsevier
dc.subject	QH301 Biology
dc.title	Hepatotoxicity of dimethylnitrosamine in cats and lizards
dc.type	Article

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