Phytochemical screening and antioxidant parameters data in prostatic rats fed with Laportea aestuans leaves
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Elseiver
Abstract
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Several plants have been used in ancient times as medicines to
treat, manage and prevent many diseases in various traditional
settings throughout the world. The effect of administration of
hydro-ethanolic extract of Laportea aestuans (La) leaves at different
doses in Wistar rats induced with benign prostatic hyperplasia
(BPH) using antioxidant parameters and phytochemical screening
data was obtained. Thirty (30) animals were randomly divided into
six (6) groups (A-F) of five (5) animals each. BPH was induced in
the animals by daily subcutaneous injection of testosterone propionate
(TP) (3 mg/kg) in olive oil and administration of treatments
for four (4) weeks were done concurrently. Group A
received olive oil alone subcutaneously, group B was induced with
BPH alone, groups C-E were induced with BPH but received different
doses of La at 100, 200 and 400 mg/kg. Lastly, group F was
induced with BPH but treated with finasteride (5 mg/kg) which
serves as the positive control group. Phytochemical screening data
of saponins, flavonoids (0.5010 7 0.0009 mg/ml), alkaloids
(0.528 mg/ml), phenols (0.6195 7 0.0015 mg/ml), tannins (0.5410
7 0.0013 mg/ml) and steroids (1.6230 7 0.0210 mg/ml) in hydroethanolic
extract of La. Antioxidant parameters such as superoxide
dismutase, catalase and reduced glutathione data were alsom gotten
at 400 mg/kg La (48.1 7 4.17U/mg protein), (29.43 7 1.38U/
mg protein) and (30.60 7 2.05 mg/ml) respectively when
Keywords
QD Chemistry