In vivo Antiplasmodial Activity of Crude Ethanolic and N-hexane Extracts of Moringa oleifera Leaves
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This study was carried out to determine the antiplasmodial activity of leaves of Moringa oleifera. Cold extraction method was carried out on grindedleaves to prepare the crude ethanolic and n-hexane extracts. Mice models (Mus musculus) were passaged with chloroquine resistant Plasmodium berghei,which are similar in morphology, physiology and life cycle to P. falciparumthat infect humans. Stock solutions of 5mg/mL5% DMSO were prepared and the extracts wereadministered atdifferent treatment concentrations, 50mg/kg, 100mg/kgand 200mg/kg body weight over 4days. Positive and negative control groups, Chloroquine diphosphate (25mg/kg) and 5% DMSO,respectively were set up. Crude ethanolic and n-hexane extracts of M. oleiferashowed anti-plasmodial activity at the three different concentrations used. Both crude ethanolic and n-hexane extracts of M. oleiferaleaves showed a significant inhibition of parasitaemia (p < 0.05) ranging from 74.7 to 95.6% for ethanolic extract and 59.3 to 87.9% for n-hexane extract. EC50value of crude ethanolic and n-hexane extractswere 32mg/kg and 42mg/kg body weight,respectively. M.oleifera showed potential for possible future use as an alternative to some conventional drugs.© 2016 Friends Science Publishers
Keywords
QH301 Biology, QL Zoology