In vivo antioxidant assessment of two antimalarial plants-Allamamda cathartica and Bixa orellana
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Elsevier
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Objective: To determine the free radical scavenging potentials pytochemical ethanol leaves extracts of Allamanda cathartica (A. cathartica) and Bixa orellana ( Bc.o onrsetliltaunean)t sa nodf tahdums itnhiestier reefdfe actt s5 0in m agn/tmimLa, l1a0r0ia ml agc/mtivLi taiensd. M200e tmhgo/dmsL: Btoo tAh lbetihnaon roalt se xatnradc ttheden p aladnmt isnaimstperleesd wweitrhe CwCitlh4 at 1 mL/kg body weight, in liquid paraffin (1:1, v/v) for 2 days (negative control) and compared reacti5v%e Tsuwbesetna n8c0e s(p lacebo) and vitamin E (positive control) pretreatments. Thiobarbituric acid tissues were assessed(T. BRAeRsSu)l,t sg:l utathione (GSH) and catalase (CAT) activities in blood and liver decreased In CCl4 treated rats, TBARS levels significantly increased, while and GSH and CAT levels were recorded for both plant extracts. Generally, higher TBARS for GSH values were recorded for blood than for liver homogenates; with reverse trend observed leveClsA Ts imleivlealr. tIon ctroecaospehde crooln centrations of A. cathartica extract recorded significant antioxidant for both species; alkaloids i(nvi tAa.m ciant hEa).r tRicead uacnidn gt esrupgeanros,i dssa pino nBin. so, rfellalvaonnao.i dCso wnecrleu srieocnosr:d eAd.
cathartica, possess phytochemicals that recorded significant antioxidative defense activities for brelosuodlt sa.nd
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QK Botany