Aligning Multiple Sequences with Genetic Algorithm
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Abstract
Description
The alignment of biological sequences is a crucial
tool in molecular biology and genome analysis. It helps to build
a phylogenetic tree of related DNA sequences and also to predict
the function and structure of unknown protein sequences by
aligning with other sequences whose function and structure is
already known. However, finding an optimal multiple sequence
alignment takes time and space exponential with the length or
number of sequences increases. Genetic Algorithms (GAs) are
strategies of random searching that optimize an objective
function which is a measure of alignment quality (distance) and
has the ability for exploratory search through the solution space
and exploitation of current results.
Keywords
QA75 Electronic computers. Computer science