Updates onSPOPGeneMutationsinProstateCancerand Computational InsightsFromTCGAcBioPortalDatabase

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dc.contributor.authorZakari, Suleiman
dc.contributor.authorRotimi, Solomon O.
dc.contributor.authorBholah, Chandra Tatsha
dc.contributor.authorOgunlana, OlubankeO.
dc.date.accessioned2026-02-09T09:28:53Z
dc.date.issued2025
dc.description.abstractSpeckle-type poxvirusandzinc*ngerprotein(SPOP)hasemergedasakeyfocusinprostatecancerresearchduetoitscriticalrole in regulatingtheandrogenreceptor(AR)signalingpathway./isreviewaimstocomprehensivelysummarizecurrentknowledge on SPOPgenemutationsinprostatecancer,emphasizingtheirimportanceindiseasecharacterizationandidenti*cationof therapeutic targets.Asystematicliteraturesearchwasconductedacrossmultipledatabases,includingPubMed,WebofScience, Scopus, andGoogleScholar.Inaddition,thisstudyusescomputationalapproachesanddatafromtheTCGAcBioPortaldatabase to explorethelandscapeofSPOPmutationsinprostatecancer.Afterscreening682articlesandfollowingsystematicselection steps, 56high-qualityarticleswereincluded.ComputationalanalysisofTCGAcBioPortaldatarevealedaSPOPmutation prevalence of5%-6%,alongwithsigni*cantalterationsinARsignalingandepigeneticregulation.SPOPmutationsdisrupt substrate recognition,leadingtodysregulationofdownstreampathwayssuchasARsignalingandchromatinremodeling. Notably, SPOP-mutantprostatecancersaremutuallyexclusivewithTMPRSS2-ERGfusionsandenrichedforWntpathway alterations. PatientswithSPOPmutationsdemonstrateprolongedresponsestoandrogendeprivationtherapy(ADT),although concurrent mutationsinTP53orDNArepairgenesnegativelyimpactoutcomes.Whiletheirprognosticsigni*cancecontinuesto evolve, theirimpactontheARpathwayhighlightstheirpotentialastherapeutictargets./eclinicalimplicationsofSPOP mutations aresubstantial,astheyarelinkedtovariationsintreatmentresponseanddiseaseprogression,thusservingasvaluable biomarkers forriskstrati*cationandprognosis.
dc.identifier.issnhttps://doi.org/10.1155/sci5/4084224
dc.identifier.urihttps://repository.covenantuniversity.edu.ng/handle/123456789/50594
dc.language.isoen
dc.publisherWiley Scientifica Volume 2025
dc.subjectandrogen receptor
dc.subjectprostatecancer
dc.subjectSPOPgene
dc.subjectSPOPmutations
dc.subjectTCGAcBioPortal
dc.subjecttherapeutictargets
dc.titleUpdates onSPOPGeneMutationsinProstateCancerand Computational InsightsFromTCGAcBioPortalDatabase
dc.typeArticle

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Programme: BIochemistry