Nitrosation of quaternary ammonium compounds in vivo in the Wistar rat
| dc.creator | Maduagwu, E. N. | |
| dc.date | 2008 | |
| dc.date.accessioned | 2025-03-29T19:11:49Z | |
| dc.description | 1. Animals dosed orally with nitrite (1.5 × 10−3 mol/kg) and nonyl dimethylbenzylammonium bromide (2.9 × 10−4 mol/kg) exhibit liver damage within two hours; cetyl trimethylammonium bromide plus nitrite was not significantly hepatotoxic. 2. Both nonyl dimethylbenzyl ammonium bromide and cetyl trimethylammonium bromide were demethylated by rat-liver microsomal preparations; substrate concentrations of 1 mM or more were inhibitory. 3. Bile from rats given i.p. doses of cetyl trimethylammonium bromide, nonyl dimethylbenzylammonium bromide or dodecyl dimethylbenzylammonium bromide contains only metabolites, no unchanged compounds were detected. | |
| dc.format | application/pdf | |
| dc.identifier | http://eprints.covenantuniversity.edu.ng/8011/ | |
| dc.identifier.uri | https://repository.covenantuniversity.edu.ng/handle/123456789/37396 | |
| dc.language | en | |
| dc.subject | QH301 Biology | |
| dc.title | Nitrosation of quaternary ammonium compounds in vivo in the Wistar rat | |
| dc.type | Article |
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