In Silico Gene Regulatory Network of the Maurer’s Cleft Pathway in Plasmodium falciparum

dc.creator	Isewon, Itunuoluwa, Oyelade, O. J., Brors, B., Adebiyi, Ezekiel
dc.date	2015-08-03
dc.date.accessioned	2025-03-28T17:15:50Z
dc.description	The Maurer’s clefts (MCs) are very important for the survival of Plasmodium falciparum within an infected cell as they are induced by the parasite itself in the erythrocyte for protein trafficking. The MCs form an interesting part of the parasite’s biology as they shed more light on how the parasite remodels the erythrocyte leading to host pathogenesis and death. Here, we predicted and analyzed the genetic regulatory network of genes identified to belong to the MCs using regularized graphical Gaussian model. Our network shows four major activators, their corresponding target genes, and predicted binding sites. One of these master activators is the serine repeat antigen 5 (SERA5), predominantly expressed among the SERA multigene family of P. falciparum, which is one of the blood-stage malaria vaccine candidates. Our results provide more details about functional interactions and the regulation of the genes in the MCs’ pathway of P. falciparum.
dc.format	application/pdf
dc.identifier	http://eprints.covenantuniversity.edu.ng/5810/
dc.identifier.uri	https://repository.covenantuniversity.edu.ng/handle/123456789/35188
dc.language	en
dc.subject	Q Science (General), QA75 Electronic computers. Computer science
dc.title	In Silico Gene Regulatory Network of the Maurer’s Cleft Pathway in Plasmodium falciparum
dc.type	Article

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