DUFFY ANTIGEN RECEPTOR FOR CHEMOKINES GENE POLYMORPHISMS AMONG NIGERIAN PROSTATE CANCER PATIENTS
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Prostate cancer (PCa) accounts for roughly 1.4 million incidence cases and 357,000 deaths, remaining the most common solid tumour in men globally. Genetic variation including single nucleotide polymorphisms (SNPs) contributes to the geographic disparity in some cancers including PCa, observed among black men. The Duffy Antigen Receptor for Chemokines (DARC) or Atypical Chemokine Receptor 1 (ACKR1) gene is highly polymorphic, with different variations in the population. Studies have shown that DARC/ACKR1 gene polymorphism is associated with angiogenesis and tumor growth in some cancer types. No study has been carried out yet on this gene polymorphism in PCa. This study aims to identify genetic variations in the DARC/ACKR1 gene and their association with PCa risk. Genomic DNA obtained from the blood samples of consented 146 PCa patients and 146 age-matched healthy men were genotyped for rs12075, rs2814778, rs13962, rs3027012 and rs863002 SNPs in DARC/ACKR1 gene using TaqMan® SNP Genotyping Assays. Fisher exact test was used to analyze the association between the variables. P-value of < 0.05 was considered statistically significant and all statistical analysis was performed using R programming language. This study showed the presence of mutant alleles in rs12075, rs13962 and rs2814778 among our study population. There was no significant association observed between the polymorphisms and PCa (p-value = 0.975, OR (95%CI) =1 (0, 39.0)). Future research that will include a larger sample size is recommended to provide insight into the association between these SNPs and PCa susceptibility.
Keywords
QD Chemistry, QH Natural history, RA0421 Public health. Hygiene. Preventive Medicine