Recent advances in chemistry and therapeutic potential of functionalized quinoline motifs – a review
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Quinoline, which consists of benzene fused with N-heterocyclic pyridine, has received
considerable attention as a core template in drug design because of its broad spectrum
of bioactivity. This review aims to present the recent advances in chemistry, medicinal
potential and pharmacological applications of quinoline motifs to unveil their substantial
efficacies for future drug development. Essential information in all the current and
available literature used was accessed and retrieved using different search engines and
databases, including Scopus, ISI Web of Knowledge, Google and PUBMED. Numerous derivatives of the bioactive quinolines have been harnessed via expeditious synthetic
approaches, as highlighted herein. This review reveals that quinoline is an indisputable
pharmacophore due to its tremendous benefits in medicinal chemistry research and
other valuable areas of human endeavour. The recent in vivo and in vitro screening
reported by scientists is highlighted herein, which may pave the way for novel drug
development. Owing to the array of information available and highlighted herein on the
medicinal potential of quinoline and its functionalized derivatives, a new window of
opportunity may be opened to medicinal chemists to access more biomolecular
quinolines for future drug development.
Keywords
QD Chemistry