Browsing by Author "Ajani, Olayinka O."
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Item Characterization, proximate composition and evaluation of antimicrobial activity of seed oil of Bauhinia tomentosa(Asian Network of Scientific Information) Ajani, Olayinka O.Item Effect of polyol on multiple ligand capped silver alloyed nanobimetallic particles in tri-n-octylphosphine oxide and oleic acid matrices(IOP Publishing and the Vietnam Academy of Science and Technology (VAST)) Ajani, Olayinka O.Item Expeditious synthesis and spectroscopic characterization of 2-methyl-3-substituted-quinazolin-4(3H)-one derivatives(Oriental Scientific Publishing Company) Ajani, Olayinka O.Item Exploration of the chemistry and biological properties of pyrimidine as a privileged pharmacophore in therapeutics(Academic Journals Inc.) Ajani, Olayinka O.Item Facile synthesis, characterization and antimicrobial activity of 2-alkanamino benzimidazole derivatives(Oriental Scientific Publishing) Ajani, Olayinka O.Item Functionalized benzimidazole scaffolds: privileged heterocycle for drug design in therapeutic medicine(John Wiley) Ajani, Olayinka O.Item HISTOLOGICAL STUDIES OF BREWERY SPENT GRAINS IN DIETARY PROTEIN FORMULATION IN DONRYU RATS(SENRA Academic Publisher, Burnaby, BC, Canada) Ajani, Olayinka O.Item Improvement of Nutritive Value of Sorghum-Ogi Fortified with Pawpaw (Carica papaya L)(Global Science Books, Isleworth, UK) Ajani, Olayinka O.Item Microwave assisted synthesis and antimicrobial activity of 2-quinoxalinone-3-hydrazone derivatives(Elsevier Publisher, Netherland, UK) Ajani, Olayinka O.Item Microwave-Assisted Synthesis and Evaluation of Antimicrobial Activity of 3-{3-(s-Aryl and s-Heteroaromatic)acryloyl}-2Hchromen-2-one Derivatives(John Wiley and Sons, Inc USA) Ajani, Olayinka O.Item Physical characterisation of some honey samples from North-Central Nigeria(Academic Journals) Ajani, Olayinka O.Item Preliminary studies on the seed oil of Caryota mitis: Proximate composition, phytochemical screening and evaluation of antimicrobial activity.(Academic Journals) Ajani, Olayinka O.Item Present status of quinoxaline motifs: Excellent pathfinders in therapeutic medicine(Elsevier) Ajani, Olayinka O.Item Quinazoline pharmacophore in therapeutic medicine(A Journal of the Bangladesh Pharmacological Society) Ajani, Olayinka O.Item The Importance of Murine Models and Their Resultant In Vivo Pharmacokinetics, Safety, and Efficacy Assessments for Antimalarial Drug Discovery(Preprints, 2026) Adebayo, Glory; Ayanda, Opeyemi I.; Rottmann, Matthias; Ajibaye, Olusola; Oduselu, Gbolahan; Mulindwa, Julius; Ajani, Olayinka O.; Aina, Oluwagbemig; Mäser, Pascal; Adebiyi, EzekielNew chemical entities are consistently being investigated in antimalarial drug discovery and they require animal models for toxicity and efficacy testing. Murine models in searching for novel antimalarial drugs are inevitable because they show unique similarities to human physiology during malaria pathogenesis. Therefore, they provide a preclinical basis (following in vitro assessments of newly identified lead compounds) for further assessment in the drug development pipeline. Specific mouse strains, non-humanized and humanized, have successfully been infected with rodent Plasmodium species and the human Plasmodium falciparum respectively. Infected mice provide a platform for the assessment of treatment options being sought. In vivo pharmacokinetic evaluations are necessary when determining the fate of new lead compounds in addition to the efficacy assessment of these chemical entities. This review highlights specific murine models important for antimalarial drug discovery and their resultant critical in vivo pharmacokinetic, safety, and efficacy assessments necessary for making appropriate choices of lead compoundsItem The Importance of Murine Models in Determining In Vivo Pharmacokinetics, Safety, and Efficacy in Antimalarial Drug Discovery(Pharmaceuticals (MDPI), 2025) Adebayo, Glory; Ayanda, Opeyemi I.; Rottmann, Matthias; Ajibaye, Olusola S.; Oduselu, Gbolahan; Oduselu, Gbolahan; Mulindwa, Julius; Ajani, Olayinka O.; Aina, Oluwagbemiga; Mäser, Pascal; Adebiyi, EzekielNew chemical entities are constantly being investigated towards antimalarial drug discovery, and they require animal models for toxicity and efficacy testing. Murine models show physiological similarities to humans and are therefore indispensable in the search for novel antimalarial drugs. They provide a preclinical basis (following in vitro assessments of newly identified lead compounds) for further assessment in the drug development pipeline. Specific mouse strains, non-humanized and humanized, have successfully been infected with rodent Plasmodium species and the human Plasmodium species, respectively. Infected mice provide a platform for the assessment of treatment options being sought. In vivo pharmacokinetic evaluations are necessary when determining the fate of potential antimalarials in addition to the efficacy assessment of these chemical entities. This review describes the role of murine models in the drug development pipeline. It also explains some in vivo pharmacokinetic, safety, and efficacy parameters necessary for making appropriate choices of lead compounds in antimalarial drug discovery. Despite the advantages of murine models in antimalarial drug discovery, certain limitations are also highlighted.Item Towards the conversion of carbohydrate biomass feedstocks to biofuels via hydroxylmethylfurfural(Royal Society of Chemistry) Ajani, Olayinka O.