Browsing by Author "Omonhinmin, Conrad A."

Filter results by typing the first few letters
Now showing 1 - 11 of 11
  • No Thumbnail Available
    Item
    Anti-Aging Potential of Bioactive Phytoconstituents Found in Edible Medicinal Plants: A Review
    (MDPI, 2024-06) Iweala, Emeka J.; Adurosakin, Oluwapelumi Eniola; Innocent, Ugochukwu; Omonhinmin, Conrad A.; Dania, Omoremime Elizabeth; Ugbogu, Eziuche A.
    Aging is a complex biological and physiological change that leads to a loss of function in all living organisms. Although the mechanism behind the aging process is still largely unknown, scientific studies have shown that oxidative stress and age-related low autophagy, which are associated with various chronic diseases such as cancer, diabetes, cardiovascular diseases, and neurodegenerative diseases, promote aging. Interestingly, many medicinal plants and their biologically active compounds have the ability to extend lifespan as they can inhibit oxidative stress and promote autophagy. This review evaluates and provides up-to-date information on the anti-aging potential of bioactive compounds in edible medicinal plants. In this study, seventeen (17) biologically active compounds from edible medicinal plants with anti-aging effects were reviewed. In vivo and in vitro studies showed that these biologically active compounds exhibit anti-aging effects via various mechanisms such as the activation of autophagy, increases in antioxidant enzymes, reductions in reactive oxygen species, the inhibition of inflammatory markers, and the downregulation of senescence genes. This study suggests that edible medicinal plants containing these bioactive compounds may promote health and extend lifespan. However, the exact mechanisms, effective doses, clinical trials, and chronic and genotoxic effects of bioactive compounds as anti-aging agents should be further investigated.
  • No Thumbnail Available
    Item
    Antibacterial Activity of the Essential Oil of Ocimum gratissimum L. against Multidrug-resistant Enterotoxigenic Escherichia coli
    (Trop J Phytocbem Phann Sci., 2025-06) Oranusi, Solomon Uche; Oyesile, Oluwapelumi S.; Obafemi, Yemisi D.; Akinduti, Paul A.; Omonhinmin, Conrad A.
  • No Thumbnail Available
    Item
    Dataset on characterisation of microbiome of prostate tissue and expressed prostatic secretions
    (Data in Brief (Elsevier), 2025) Akinnola, Olayemi O.; Samuel, Abosede E.; Omonhinmin, Conrad A.
    Prostate cancer (PCa) is the second most prevalent cancer in men, particularly affecting those of Black African descent. Nigeria currently has the fourth highest risk for PCa mortality in the world. The microbiome of the prostate has emerged as a critical factor in understanding the aetiology and progres- sion of prostate diseases, such as prostate cancer (PCa), be- nign prostatic hyperplasia (BPH) , benign stromal hyperpla- sia (BSH) and prostatitis (PRO). This study to comparatively characterise the microbiome present in prostate tissue and expressed prostatic secretion (EPS) from 30 study subjects diagnosed with PCa, BPH, BSH and PRO and sampled from the urology clinic of Lagos State University Teaching Hospital Ikeja. Bacterial species community composition and diversity were analysed based on 16S rRNA metagenome nucleotide data to ensure the accuracy, reproducibility, and broader ap- plicability of microbiological and genomic research. Data in- formation allows for precise identification of organisms at the species or strain level, essential for verifying experi- mental results and comparisons of the isolated organism’s genome with related strains, providing insights into genetic diversity, virulence factors, and metabolic pathways of the sample population microbiome.
  • No Thumbnail Available
    Item
    Dataset on rbcL gene intra and inter-specific diversity and phylogenetic relationship of eggplants ( Solanum species) in Southern Nigeria
    (Data in Brief (Elsevier), 2025) Ajiboye, Babafemi I.; Popoola, Jacob O.; Eni, Angela O.; Omonhinmin, Conrad A.
    Eggplant ( Solanum sp.) is the third most widely cultivated solanaceous vegetable globally, and it is commonly con- sumed in Nigeria, particularly in Southern Nigeria, for its nutritious and medicinal fruit, leaves, and seeds. The taxon has recorded array of ethnobotanical uses ranging from food, medicine to cultural interactions in ceremonies. Despite the enormous range of a value, studies have shown decreas- ing eggplant varietal diversity, directly linked with cultiva- tion preferences and activities, such as exchanging propag- ules within and between agroecological areas and farms. Ad- ditionally, the wide range of accessions in the taxa, mor- phological plasticity, and genetic similarity among acces- sions have resulted in the ambiguity and inconsistent phy- logenetic classification of the taxa. The dataset consists of partial ribulose-1,5-bisphosphate carboxylase/oxygenase large subunit ( rbcL ) gene sequences, nucleotide compositions and amino acid profiles of 75 accessions of eggplants collected from across Southern Nigeria. The genetic information pro- vided by the dataset offers insight into the genetic diversity and the phylogenetic relationships of the eggplant accessions, which could serve as a baseline for designing effective strate- gies for sustainable cultivation, conservation, utilisation, and improvement of the taxa.
  • No Thumbnail Available
    Item
    Dataset on rbcL-based intra-specific diversity and population structure of Parkia biglobosa (Jacq.) in Nigeria
    (Data in Brief (Elsevier), 2024) Omonhinmin, Conrad A.; Taiwo, Nchedo S.; Okonkwor. Paul B.; Ajayi, Israel M.; Akinduti, Paul Akinniyi; Aworunse, Oluwadurotimi S.; Ajiboye, Ibukun; Taiwo, Olugbenga S.; Adekeye, Bosede Temitope; Oziegbe, Olubukola; Bello, Adetutu O.; Ahuekwe, Eze Frank; Oyekanmi, Joshua; Olufowobi, Olanrewaju; Oniha, Margaret Ikhiwili; Oshamika, Oyewumi; Ejoh, Samuel A.; Adewale, Adeyemi G.; Akinnola, Olayemi O.; Oranusi, Solomon U.; Popoola, Jacob O.
    African locust bean ( Parkia biglobosa ) is a multipurpose legu- minous tree species of nutritional and pharmacological value. The plant is widely distributed in Africa and across Nige- ria’s major agroecological areas (AEAs). Amidst declining cul- tivation and production, P. biglobosa is genetically threatened in its natural habitats due to overexploitation, deforestation, wildfires and lack of improved tree management practices. Consequently, concerted research efforts directed towards germplasm collection and assessment of genetic relation- ships are imperative for conserving its genetic resources, sustainable management and selecting promising landraces for breeding programmes. The dataset presents rbcL in- traspecific genetic diversity and population structure of 62 P. biglobosa landraces in Nigeria. A relatively high level of diversity and a low degree of nucleotide variability was observed among the landraces. Relatively high values of 642 total allele sites, 601 polymorphic sites, 504 parsimony information sites, 883 total number mutations, 9 haplotypes and 0.55 gene diversity were recorded for the sequence dataset. Low values of 0.35 nucleotide diversity and 5 InDels events were also recorded for the dataset. The gene flow in this dataset demonstrated an extensive exchange of genes between the three populations of P. biglobosa, which influenced the level of genetic differentiation (Gst) between the populations. Significantly low Gst (-0.01) was recorded between the Guinea and Sudan savannah populations, a moderate value (0.03) was recorded between the Sudan savannah and Rainforest populations and a higher Gst value (0.05) was recorded between the Guinea and Rainforest populations. The dataset highlights potential evolutionary dynamics that might influence variations relevant to the breeding and conservation of P. biglobosa in Nigeria and across its range in West and Central Africa.
  • No Thumbnail Available
    Item
  • No Thumbnail Available
    Item
  • No Thumbnail Available
    Item
    Ethnopharmacological relevance, phytochemistry, potential health benefits and toxicity profile of Ananas comosus (L.) Merr (pineapple)
    (Pharmacological Research - Natural Products 10 ( Elsevier), 2026) Ugbogu, Eziuche A.; Iweala, Emeka Joshua; Ukachukwu, Chukwudi Eke; Babayo, Christy; Dania, Omoremime Elizabeth; Isreal, Chollom Longs; Omonhinmin, Conrad A.; Cleanclay, Wisdom D.; Okoro, Benedict Chukwuebuka
    In traditional medicine, the cortexes of A. comosus are used as an alexipharmic, antitussive, and antidiarrheal agent, while the leaves are commonly used as a remedy for indigestion. This review provides a thorough and upto- date literature on the ethnopharmacological uses, phytochemistry, and potential health benefits of A. comosus. The articles used for this study were obtained from databases such as ScienceDirect, Frontiersin, PubMed, Springer, and MDPI. In addition, only articles written in English were included in this review. Phytochemical analysis revealed that A. comosus contains numerous biologically active compounds, including n-hexadecanoic acid, bromelain, n-heptadecanol-1, methyl ester, hexadecanoic acid, squalene, α-tocopherol, tetradecane, 5- hydroxymethylfurfural, dihydroxyacetone, dodecane, DL-α-tocopherol, furan methanol, dodecanoic acid, and 2,4,6-cycloheptatrien-1-one, among others. Various in vivo and in vitro biochemical studies have also shown that A. comosus possesses antioxidant, anti-inflammatory, anticancer, antidiarrheal, antimicrobial, antimalarial, cardioprotective, anthelmintic, and antidiabetic properties. Therefore, this review shows the biologically active compounds in A. comosus and the potential of different parts of A. comosus to prevent and treat various diseases. While A. comosus has shown promise in animal studies, human clinical trials are needed to determine safe and effective doses. Further research may reveal additional uses for this versatile plant as a functional food and in modern healthcare as a traditional and complementary alternative medicine.
  • No Thumbnail Available
    Item
  • No Thumbnail Available
    Item
  • No Thumbnail Available
    Item