Department of Chemistry
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Item Complexes of SCN and dithiol ligands for solvothermal green synthesis of high indexed binary PbS and SnS semiconductor nanoparticles(Journal of the Indian Chemical Society Volume 102, Issue 6,, 2025-06) Adekoya, Joseph Adeyemi; Oyeku, Pelumi Olusola; Edidiong, Sunday Sam; Adeniyi, Adeleke Ayoola; Almalki, Abdulraheem S. A; Mersal, Gaber A.M.; Ibrahim, Mohamed M.; Revaprasadu, NeerishItem Biosynthesis, characterization, and antimicrobial study of zinc oxide nanoparticles using Adonida merrilli leaf extract(International Conference on Science, Engineering and Business for Driving Sustainable Development Goals, 2024) Owoeye, Taiwo Felicia; Bamisaye, Abayomi; Adekoya, Joseph Adeyemi; Afolalu, Sunday A.; Monye, Stella Isioma; Ojo, Augustine OluwatyinThe utilization of plant-mediated methods to synthesize metal oxide nanoparticles (NPs) is becoming increasingly popular due to its simplicity, low cost, and environmental friendliness. Adonida merrilli leaf extracts in aqueous form were used for the production of nanoparticles of zinc oxide (ZnO). scanning electron microscope with energy dispersive X-ray (SEM-EDX), Fourier transform infrared spectrometer (FTIR), X-ray diffractometry (XRD), and UV-Vis spectrophotometer were accustomed to analyze the ZnO nanoparticles. The antibacterial effects of the ZnO NPs was examined on pathogens such Salmonella, Candida, Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa.XRD indicate spherical crystalline nanoparticles with an average particle size of 73.82 nm. Zinc oxide nanoparticle absorption wavenumber at 715 cm-1 was seen in the FTIR, and EDX chemical mapping confirms the elemental composition of zinc and oxygen. For Candida, Salmonella, Pseudomonas aeruginosa, Escherichia coli, and Staphylococcus aureus measured Zones of Inhibition (ZI) values are 30.00, 36.00, 32.00, 40.00, and 36.00 mm, and the measured Minimum Inhibitory Concentration (MIC) values are 7.81, 1.95, 7.81, 1.95, and 3.90 mg/mL, respectively. The results of this investigation, as shown by the MIC and ZI values, point to the possible use of Adonida merrilli extract in the synthesis of highly crystalline Zinc oxide nanoparticles (ZnONPs) as an alternative medication.Item Amino-functionalised mesoporous silica nanoparticles for the delivery of isoniazid and its metal complexes(Materials Chemistry and Physics Volume 326, 2024) Tella, Josephine Oluwagbemisola; Adekoya, Joseph Adeyemi; Ajanaku, Kolawole Oluseyi; Banerjee, Rajkumar; Patra, Chitta Ranjan; Pavuluri, Srinivasu; Sreedhar, BojjaThe effective delivery of poor water-soluble anti-tubercular drugs such as isoniazid to their target sites is a major factor that has made it difficult for tuberculosis to be eradicated. Isoniazid derivatives and nano-particulate drug delivery systems are explored as one way to address this limitation. This study investigated the use of amino functionalised mesoporous silica nanoparticles (MCM-41) as nano-carriers for the delivery of isoniazid-based metal complexes, Cu–INH and Fe–INH. The Sol-gel method was used to synthesise the nano-carriers, which produced a series of well-ordered nano-carriers. Their physicochemical properties were modified through surface functionalisation with amino groups via post-grafting synthesis. The isoniazid based metal complexes were incorporated into the nano-carriers using rotary evaporation. The nano-carriers were characterised using X-ray diffraction (XRD), Zeta potential, Fourier Transmission Infra-red (FT-IR), Brunaeur Emmett Teller (BET), Scanning Electron Microscopy (SEM), Transmission Electron Microscopy (TEM) and Thermogravimetric analysis (TGA). These characterisation techniques confirmed the successful surface functionalisation of the nano-carriers with amino groups and their encapsulation with INH, Cu–INH and Fe–INH. The amino-functionalised nano-carriers were observed to have the highest drug loading capacities and entrapment efficiencies within the range of 7.85%–19.31 % and 39.26%–96.53 %, respectively. The release rates of INH, Cu–INH, and Fe–INH from the nano-carriers were also studied in Phosphate Buffer Solution (PBS) with pH of 7.4 and 5.4 using ultraviolet–visible spectroscopy. The cumulative release rates of INH, Cu–INH, and Fe–INH from their nano-carriers depended on their release media's textural properties and environmental conditions. Amino functionalised nano-carriers had high release rates, with A-MCM 41+Cu–INH having the highest of 37.09 % in PBS at 5.4 after 24 h. The cumulative data obtained was fitted into Zero order, First order, Hixson Crowell, Higuchi, Korsmeyer Peppas and Weibull models. The Hixson Crowell, Korsmeyer-Peppas, and Weibull models fitted well with correlation coefficients (R2) of 0.9813, 0.9769 and 0.9802, respectively, for MCM-41+INH in PBS of pH 5.4.