Department of Chemistry

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Author: search.filters.author.Akinsiku, Anuoluwa Abimbola

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    Photocatalytic Activity of Green Mixed Matrix Membranes for Degradation of Anionic Dye
    (Green Chemistry for Sustainable Water Purification, 2022-12-27) Oladipo, Gabriel Opeoluwa; Alayande, Samson Oluwagbemiga; Ogunyinka, Opeyemi O; Akinsiku, Anuoluwa Abimbola; Akinsipo-Oyelaja, Oyesolape Basirat; Ofudje, Edwin Andrew; Bolarinwa, Hakeem S.; Akinlabi, Akinola Kehinde; Msagati, Titus. A.M.
    Anionic dye is a notable constituent of textile effluent, which renders water unsafe for human and animal use. A notable approach to mitigating effluent is the use of membranes. In this study, a mixed matrix technique was adopted for the preparation of composite membranes. The composite membranes consist of crumb rubber filled with nanoparticles, respectively. The membranes were characterized by Fourier transform spectroscopy, scanning electron microscopy coupled with energy dispersive x-ray, thermogravimetric analyser, and drop shape analyzer. The photocatalytic activities of the mixed matrix membranes were investigated with anionic dye in the UV/visible region. Photocatalytic activity of composite membranes showed high degradation with an apparent rate constant. This study presents a rubber-based membrane for wastewater treatment.
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    Advances in nanoparticles as drug delivery systems: A review
    (Scientific African, 2025) Akomolafe, Oluwatobi Abayomi; Akinsiku, Anuoluwa Abimbola
    The use of nanoparticles in the pharmaceutical sector as drug carriers is rapidly growing, with many benefits over conventional drug delivery procedures. These nanoscale carriers are composed of biodegradable biocompatible materials, delivering therapeutic agents to the target with precise control and mitigating unwanted side effects. Despite numerous reports, many research gaps remain; thus, opportunities to improve the specificity and effectiveness of nanoparticle-based drug delivery for various illnesses, such as cancer, cardiovascular disease, infectious diseases, and central nervous system (CNS) disorders, are identified. The advances in nanoparticle-based drug delivery and their tremendous potential for revolutionising how drugs are delivered to treat disease are discussed. This review provides an overview of the various types of nanoparticles, including lipid-based, polymeric, natural polymers, and inorganic nanoparticles, which are being developed with their unique physical and chemical characteristics. It also reveals the strategies employed to enhance the targeting efficacy and stability of these nanoscale carriers in nanomedicine. The advantages, mechanisms, future direction, and drawbacks of each nanoparticle-based drug delivery system in target therapy and personalised medicine are well reviewed. Thus, addressing the identified gaps will be crucial for the clinical translation of nanoparticle-based therapeutics.
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    Antimicrobial and cytotoxicity evaluation of Annona muricata-based silver-cobalt nanoparticles on WEHI 164 cell line
    (Results in Chemistry, 2025) Akinsiku, Anuoluwa Abimbola; Odaudu, Ruth Opiotu; Ejilude, Oluwaseun
    The harsh chemicals in conventionally fabricated metal nanoparticles have limited their applications for biomedical purposes. As part of green and sustainable chemistry in this study, an aqueous extract of indigenous Annona muricata was a reductant in preparing silver‑cobalt nanoparticles (Ag Co NPs) for therapeutic appli cation. The reaction progress and rate of formation of nanoparticles were monitored with a UV–visible spec trophotometer. The functional groups, structural morphology, and elemental composition of the Ag Co NPs were confirmed using FTIR, SEM, TEM, and EDX techniques, respectively. This study evaluated the cytotoxicity potential of 21.38± 8.0 nm Ag–– Co NPs on the WEHI 164 cell line for the first time, using an MTT assay and the antimicrobial potential of Ag Co NPs against six microorganisms. The characteristic wavelength of absorption was observed between 400 and 450 nm. The antimicrobial test showed evident growth inhibition by Ag Co NPs on P. aeruginosa, Candida albicans and Aspergillus niger. The in vitro cytotoxicity evaluation on the WEHI 164 cell line indicated that the Ag–– Co NPs were cytotoxic at an IC 50 dosage of 84 concentration-dependent. Hence, the Annona muricata synthesised Ag μ g/mL, and the cytotoxic potential was Co NPs are potential pharmaceutical drug candidates.