College of Science and Technology

Permanent URI for this communityhttp://itsupport.cu.edu.ng:4000/handle/123456789/28738

Welcome to the community of research works in Science and Technology

Browse

Now showing 1 - 20 of 38

Students’ satisfaction with lighting in classrooms: A case study of a college building in Covenant University, Ota, Nigeria
(Journal of The Nigerian Institute of Architects Vol. 2, 2024) Sholanke Anthony Babatunde; Ekhaese Eghosa N.; Jegede Foluke O.; Omokanye Lois A.
Quality lighting is essential for performing academic tasks in educational environments. Poor lighting is a hindrance to effective teaching and learning, especially in classrooms. Users' satisfaction with the quality of light in educational settings is therefore essential for enabling effective delivery of quality education. This study investigated students' satisfaction with lighting in classrooms in a college building at Covenant University, Ota, Nigeria, with a view to identify grey areas that require improvements, towards making contributions on ways of developing sustainable educational environment that meet users' lighting needs. The study adopted a mixed research approach that utilized both qualitative and quantitative research methods. Qualitative data was collected with the aid of an observation guide and content analysed. Whereas, quantitative data was gathered from 100 undergraduate final year students with a closed-ended structured questionnaire and analysed with the Statistical Product and Service Solutions software. Descriptive approach with the aid of photographic images and tables were used to present the findings. The study discovered that natural lighting is admitted into the classrooms through side windows and clerestory windows, while light emitting diode blubs are the artificial lighting means used. Both lighting mediums were found to be adequate. Majority of the respondents equally found the lighting means effective to indicate that they are fit for purpose. The study underscored the importance of making appropriate provisions for both natural and artificial lighting in learning spaces as a way to enhance students’ concentration level through the provision of effective natural and artificial lighting in academic environments, which in turn has the potential to enhance their academic performance.
Users’ Circulation Preferences in Train Terminals in Lagos State, Nigeria
(Information Classification: General, 2025) Oluwatayo, Adedapo Adewunmi; Nzeh Millicent Eberechukwu
Train terminals serve as vital nodes within the urban transportation networks by facilitating the seamless movement of millions of passengers daily. However, due to the continuous rise in passenger numbers and the increasing complexity of designed train terminals, passenger circulation experiences and satisfaction levels are often hindered. This study evaluated users’ circulation preferences in Lagos, Nigeria, aimed at identifying the strategies that enable effective user-centric and improved train terminal layouts. This study adopted mixed methods research, which involved the distribution of digitalised survey questionnaires to collect data from sixty-two users of three existing train terminals in Lagos, Nigeria, namely: Babatunde Fashola Train Station, Mobolaji Johnson Train Station and Ikeja Train Station. Using IBM SPSS version 27, the data on the twenty-six user circulation variables were thoroughly analysed using descriptive statistics, and the results were presented in an orderly manner using tables. The results show that common areas of dissatisfaction were the accessibility for all users, the number and width of escalators/lifts, and the ease of wayfinding within the train stations. Therefore, it is recommended that, for improved user circulation within train terminals, the design and number of vertical circulation systems present within train terminals should be significantly improved, while enhancing easy evacuation during emergency situations
Influence of Architectural Education on Sustainable Design Thinking: A Review of Energy-Efficiency Concepts
(IOP Conf. Series: Earth and Environmental Science, 2025) Sholanke Anthony Babatunde; Nwangwu C. I.
The integration of sustainable design thinking in architectural practice is crucial for addressing energy efficiency challenges. However, the influence of architectural education on fostering such thinking remains underexplored. In order to solve this problem, this study examined how teaching architecture promotes sustainable design thinking, with a focus on energy-efficiency. It examined existing literature and case studies to evaluate teaching techniques in architecture schools and made a case for a curriculum that incorporates energy-efficient design concepts and fosters a sustainable culture within the programme. Through literature review by content analysis and selective approach of study, the results and findings show that there are significant barriers to the effective implementation of sustainable design education, such as: lack of faculty knowledge, lack of funds, and obsolete assessment techniques. The study concludes that greater collaborative efforts across stakeholders are needed to overcome these difficulties and establish a sustainable culture in architectural education It is envisaged that this study will encourage architects to design environmentally friendly and energy-efficient schemes. The study offers helpful information for creating curricula and formulating policies for education in sustainable design.
The Influence of Pedestrian Circulation Strategies on User Experience in Train Terminals
(International Journal of Transport Development and Integration, 2025) Oluwatayo, Adedapo Adewunmi ; Nzeh, Millicent Eberechukwu
Global urbanisation is evident in Sub-Saharan Africa, especially Nigeria, where the population has steadily increased by 3.2% annually. This increment necessitates the adoption of sustainable public transportation, with rail transport leading the advancement. However, train terminals are fraught with complex and poorly implemented approaches to pedestrian circulation. This study evaluated the implementation of pedestrian circulation strategies within three existing train terminals in Lagos, Nigeria, aimed at determining their influence on optimal user experience. The research method employed in this study is a mixed-method approach, which entailed the distribution of survey questionnaires to 60 respondents. Thereafter, descriptive statistics were thoroughly carried out using the IBM Statistical Package for Social Sciences (SPSS) version 27. The results show that the pedestrian circulation strategy that influenced user experience the most within the selected train terminals was the connection of corridors and lobbies with other facilities. Therefore, it is recommended that horizontal pedestrian circulation strategies should be appropriately spatially planned and dimensioned to accommodate high pedestrian traffic scenarios within train terminals.
CHARACTERISATION OF PROSTATE TISSUE AND EXPRESSED PROSTATIC SECRETION IN PATIENTS WITH PROSTATE DISORDERS IN LAGOS NIGERIA
(Covenant University Ota, 2025-01) SAMUEL ABOSEDE ESTHER; Covenant University Ota
Prostate cancer (PCa) is the second most prevalent cancer in men, particularly affecting those of Black African descent. Nigeria currently has the fourth highest risk for PCa mortality in the world. The microbiome of the prostate has emerged as a critical factor in understanding the aetiology and progression of prostate diseases, such as prostate cancer (PCa), benign prostatic hyperplasia (BPH), benign stromal hyperplasia (BSH) and prostatitis (PRO). This study was conducted to comparatively characterize the microbiome present in prostate tissue and expressed prostatic secretion (EPS) from patients diagnosed with PCa, BPH, BSH and PRO. A total of 30 study participants comprising of 15 prostate cancer, 10 benign prostatic hyperplasia, 2 benign stromal hyperplasia and 3 prostatitis subjects. Samples were collected from the urology clinic of Lagos State University Teaching Hospital Ikeja and analysed to identify and quantify bacterial species, assessing the diversity and composition of the microbial communities. Subjects without prostate (15) cancer were used as control subjects. By employing cultural and 16SrRNA sequencing techniques, uro-pathogens were isolated from the samples. The antibiotic susceptibility testing was carried out on these isolates. Prostate tissue and EPS samples from BPH patients demonstrated a higher prevalence of bacterial taxa, including Staphylococcus scuri, Bacillus mycoides, Staphylococcus aureus, Proteus vulgaris, Klebsiella pneumoniae, Pseudomonas aeruginosa, Streptococcus pyogene and Bacillus subtilis. Conversely, PCa patients exhibited an increased presence of pathogenic bacteria such as Escherichia coli Klebsiella oxytoca, Pseudomonas fluorescens, Citrobacter freudii, Pseudomonas putida, Staphylococcus condimentii, and Proteus mirabilis, which have been implicated in chronic inflammation and carcinogenesis. A high abundance of Lactobacillus vaginalis, Staphylococcus carnosus and Zymononas mobilis were observed in the prostate tissue. PCa-associated microbiome displayed reduced microbial diversity compared to other prostate disorders, suggesting a possible dysbiosis linked to cancer progression.
EVALUATION OF COST REDUCTION TECHNIQUES ON PUBLIC TERTIARY EDUCATIONAL PROJECTS IN SOUTHWESTERN NIGERIA
(Covenant University Ota, 2025-03) AKINOLA GBEMISOLA AJOKE; Covenant University Thesis
In-Silico, Nutritional and Anti-inflammatory Studies on Trametes versicolor (L.) Lloyd and Flammulina velutipes (Curtis) Singer
(Covenant University Ota, 2025-03) IYEKEKPOLOR, OSAMUDIAME MOSES; Covenant University, Dissertation
Mushrooms are recognized as functional foods due to their rich phytochemical diversity and nutritional and therapeutic value. This study investigated the health-promoting potential of two understudied species, Trametes versicolor and Flammulina velutipes, through an approach that integrated phytochemical analysis, nutritional profiling, anti-inflammatory investigation, and in-silico evaluation. Preliminary phytochemical screening was carried out using standard methods. Proximate and micronutrient analyses were carried out using AOAC methods. High-performance Liquid Chromatography (HPLC) was utilized for bioactive compound quantification. Anti-inflammatory activity was investigated via the albumin denaturation assay and compared with a standard anti-inflammatory drug (Prednisolone). Molecular docking was performed using the Swiss dock platform utilizing the AutoDock Vina algorithm. Preliminary phytochemical screening identified T.versicolor as rich in saponins, phenols, tannins, glycosides, and emodins, while F.velutipes contained high flavonoids, alkaloids, saponins, and phenols. Nutritional profiling revealed F.velutipes as a nutrient-dense species with higher energy (491.57 kcal/100g), protein (24.71%), and fiber (15.12%) compared to Trametes versicolor (426.73 kcal/100g, 19.66% protein, 12.42% fiber). Both mushrooms exhibited significant mineral content, including potassium, magnesium, and calcium, with F.velutipes containing elevated vitamin C (77.54 mg/100g) and T.versicolor higher vitamin B2 (2.46 mg/100g). Anti-inflammatory activity, revealed T. versicolor exhibited low potency (IC50 1.073 × 1010 μg/mL), whereas F. velutipes exhibited superior efficacy (IC50 2.858μg/mL), outperforming prednisolone (IC50 2.231 × 1014 μg/mL). Computational molecular docking against HER2, a breast cancer target, revealed T.versicolor’s bioactive compounds—rutin, apigenin, and kaempferol—with binding affinities of -5.88, -5.81, and -5.78 kcal/mol, respectively, comparable to the standard drug doxorubicin (-5.43 kcal/mol). Similarly, F.velutipes’ orientin and catechin showed binding affinities of -5.24 and -5.70 kcal/mol, highlighting their anticancer potential. These findings underscore both species as nutrient-rich functional foods with robust anti-inflammatory activity and promising therapeutic relevance against breast cancer.
Frequency Of BRCA1 Polymorphisms (rs799917 and rs1799966) Among Nigerian Breast Cancer Patients
(Covenant University Ota, 2025-03) OGUNNIYI, OLUWABUSAYO BUNMI; Covenant University, Dissertation
Breast cancer (BCa) is the most diagnosed malignancy among women worldwide, with an estimated 2.3 million new cases and 666,103 deaths recorded in 2022. In Nigeria, BCa remains the leading cause of cancer-related mortality among women, accounting for 32,278 (25.3%) new cases and 16,322 (20.5%) deaths in 2022. Breast cancer gene 1 (BRCA1) is a tumour suppressor gene involved in DNA damage repair, cell cycle regulation, and maintenance of genome stability. Studies suggest that genetic factors, such as Single Nucleotide Polymorphism (SNPs) in the BRCA1 genes, play a pivotal role in the development of cancers. The BRCA1 gene harbors specific SNPs within its coding sequence, including rs799917 and rs1799966. These SNPs interfere with the interaction between BRCA1 mRNA and miR-638, significantly decreasing BRCA1 expression among individuals carrying these variants. Several studies have reported correlations between BRCA1 polymorphisms rs799917 and rs1799966 with the risk of BCa. However, this relationship remains controversial. This study assesses the frequency of BRCA1 rs799917 and rs1799966 polymorphisms and their association with BCa in Nigeria. The case-control study included 500 BCa patients and 200 paired healthy controls. TaqMan genotyping assay was used to determine the genotypes of rs799917 and rs1799966 polymorphisms. Using logistic regression and Pearson's chi-square test, a statistically significant difference (p < 0.05) was identified in the genotype frequencies. The G allele of rs799917(p= 0.017; OR: 1.39) showed significant associations with the risk of breast cancer in Nigeria and, while globally reported as the wild-type allele, is observed as the variant allele in our population. The C Allele of rs1799966 confers a protective risk against breast cancer. Further study should focus on functional genomics to evaluate the interaction between miR-638 and the mRNA in individuals carrying this SNP, particularly in the Nigerian population. Keywords: breast
GENETIC POLYMORPHISMS IN ERCC6 AND CYP17A1 AND THEIR ASSOCIATION WITH VITAMIN-D LEVELS IN NIGERIAN PROSTATE CANCER PATIENTS
(Covenant University Ota, 2025-04) AMADI EMMANUEL CHIMUEBUKA; Covenant Uniersity Dissertation
Prostate cancer (PCa) constitutes the principal cause of cancer-related deaths among males over 40 in Africa, especially in Nigeria. By 2030, 10.8% of males may develop PCa before 75. The aggressiveness of PCa in Blacks versus Caucasians is not well understood. Mutations in tumour-specific genes like Excision Repair Cross-Complementation Group 6 (ERCC6) and Cytochrome P450 Family 17 Subfamily A Member 1 (CYP17A1) may serve as diagnostic biomarkers. ERCC6, involved in DNA repair, and CYP17A1, key in androgen production, are linked to PCa progression. This study assessed ERCC6 rs2228528 and CYP17A1 rs4919686 polymorphisms and their relation to vitamin D (VD) and androgen receptor (AR) levels in Nigerian PCa patients. Vitamin D (VD) insufficiency is linked with increased prostate cancer (PCa) mortality and influences energy metabolism in normal prostate cells. The Androgen Receptor (AR) regulates vital genes in prostate cancer development and is more common in Black populations. Exploring ERCC6 and CYP17A1 in relation to VD and AR could improve PCa diagnosis. This study evaluated the association between ERCC6 rs2228528 (C > T) and CYP17A1 rs4919686 (A > C) polymorphisms, located in ERCC6 exon 11 and the CYP17A1 promoter, respectively, vis-à-vis VD and AR levels in Nigerian PCa patients. Genotyping employed real-time PCR with TaqMan assays, while enzyme-linked immunosorbent assay (ELISA) was used to measure VD and AR levels. The data was then analysed using Excel, SPSS, and R. Results revealed a higher presence of ERCC6 rs2228528 wildtype genotypes in cases (37%) compared to controls (30%) and a lower presence of CYP17A1 rs4919686 wildtype genotypes in cases (46%) versus controls (48%). No significant associations (p > 0.05) were found between these polymorphisms. Nevertheless, rs2228528 shows promise as a PCa biomarker. VD levels were higher in cases (52.49 ng/mL) than in control (47.93 ng/mL), while difference in androgen levels were not significant (p > 0.05). Lastly, ERCC6 polymorphism, but not CYP17A1, shows potential as a possible biomarker for PCa. Larger studies are needed for definitive conclusions. Keywords: Black Populations and Cancer, Gene
GENETIC POLYMORPHISMS IN ERCC6 AND CYP17A1 AND THEIR ASSOCIATION WITH VITAMIN-D LEVELS IN NIGERIAN PROSTATE CANCER PATIENTS
(Covenant University Ota, 2025-04) AMADI, EMMANUEL CHIMUEBUKA; Covenant University Dissertation
Prostate cancer (PCa) constitutes the principal cause of cancer-related deaths among males over 40 in Africa, especially in Nigeria. By 2030, 10.8% of males may develop PCa before 75. The aggressiveness of PCa in Blacks versus Caucasians is not well understood. Mutations in tumour-specific genes like Excision Repair Cross-Complementation Group 6 (ERCC6) and Cytochrome P450 Family 17 Subfamily A Member 1 (CYP17A1) may serve as diagnostic biomarkers. ERCC6, involved in DNA repair, and CYP17A1, key in androgen production, are linked to PCa progression. This study assessed ERCC6 rs2228528 and CYP17A1 rs4919686 polymorphisms and their relation to vitamin D (VD) and androgen receptor (AR) levels in Nigerian PCa patients. Vitamin D (VD) insufficiency is linked with increased prostate cancer (PCa) mortality and influences energy metabolism in normal prostate cells. The Androgen Receptor (AR) regulates vital genes in prostate cancer development and is more common in Black populations. Exploring ERCC6 and CYP17A1 in relation to VD and AR could improve PCa diagnosis. This study evaluated the association between ERCC6 rs2228528 (C > T) and CYP17A1 rs4919686 (A > C) polymorphisms, located in ERCC6 exon 11 and the CYP17A1 promoter, respectively, vis-à-vis VD and AR levels in Nigerian PCa patients. Genotyping employed real-time PCR with TaqMan assays, while enzyme-linked immunosorbent assay (ELISA) was used to measure VD and AR levels. The data was then analysed using Excel, SPSS, and R. Results revealed a higher presence of ERCC6 rs2228528 wildtype genotypes in cases (37%) compared to controls (30%) and a lower presence of CYP17A1 rs4919686 wildtype genotypes in cases (46%) versus controls (48%). No significant associations (p > 0.05) were found between these polymorphisms. Nevertheless, rs2228528 shows promise as a PCa biomarker. VD levels were higher in cases (52.49 ng/mL) than in control (47.93 ng/mL), while difference in androgen levels were not significant (p > 0.05). Lastly, ERCC6 polymorphism, but not CYP17A1, shows potential as a possible biomarker for PCa. Larger studies are needed for definitive conclusions.
EFFECTS OF JOBELYN® AND RESVERATROL ON BISPHENOL-A-INDUCED MALE REPRODUCTIVE DYSFUNCTIONS IN WISTAR RATS
(Covenant University Ota, 2025-04) FASANYA, CHRISTIANAH BOLUWATIFE
Recent years have shown a significant deterioration in sperm quality among men, largely attributed to prolonged exposure to environmental endocrine disruptors. Bisphenol-A (BPA), a prominent disruptor, contributes to this issue by inducing oxidative stress and disrupting the hypothalamus-pituitary-gonadal axis. The study aims to examine the effects of Resveratrol and Jobelyn on reproductive dysfunction in BPA-induced male rats. BPA was exposed to forty-two male rats, grouped into six. Every group—aside from the control, were exposed to 200 mg/kg of BPA. The treatment groups included: Group 3, which received 20 mg/kg of Resveratrol; Group 4, treated with 5 mg/kg of clomiphene citrate; Groups 5 and 6, administered 100 mg/kg and 200 mg/kg of Jobelyn, respectively; and Group 7 received a combined dose of 200 mg/kg of Jobelyn and 20 mg/kg of Resveratrol. This experiment was conducted over a duration of 28 days. The testicular, and epididymal antioxidant enzymes (glutathione-S-transferase and superoxide dismutase) and the malondialdehyde (MDA) level were evaluated. The sperm quality and serum hormonal (luteinizing hormone, testosterone, and follicle stimulating hormone) concentration were also evaluated. The results revealed that exposure to BPA significantly (p<0.05) reduced the sperm quality, activity of antioxidant enzymes, and hormonal levels compared to the control group, while it caused an increase in malondialdehyde (MDA) levels. Treatment with Jobelyn and Resveratrol significantly (p<0.05) improved sperm quality and hormonal levels, enhanced antioxidant enzyme activity, and reduced malondialdehyde (MDA) levels in comparison to BPA-induced rats. The histopathology analysis showed no structural or cellular alteration to the testes and epididymis. This study suggests that Jobelyn and Resveratrol may be beneficial in managing hormonal imbalances caused by oxidative stress in men.
MOLECULAR DOCKING, LIGAND QUALITY AND ANTIPLASMODIAL EVALUATION OF BENZAMIDE, COUMARIN AND BENZODIAZEPINE ANALOGS
(Covenant University Ota, 2025-04) ADEBAYO GLORY PIPELOLUWA; Covenant University Thesis
Malaria chemotherapy is an essential strategy for malaria elimination but resistance has challenged existing antimalarials, including frontline artemisinin combination therapy (ACT); hence, new antimalarial drugs must be discovered and developed. This study investigated the antiplasmodial efficacy and cytotoxicity through in vitro models while also testing the antiplasmodial efficacy, and the in vivo acute toxicity of benzamide, coumarin and benzodiazepine analogss. This study also evaluated the ligand quality of the molecules and their possible Plasmodium falciparum protein targets. Three molecules, 4- amino-N-hydroxybenzamide (AHB), ethyl 2-oxo-2H-chromene-3-carboxylate (ECC), and 2,2,4-trimethyl-2-3-dihyro-1H-benzo[b][1,4] diazepine (BDZ) were screened for their in vitro antiplasmodial activities tested against P. falciparum 3D7 standard strain using the SYBR Green Dye I measuring IC50 and their cytotoxicities against MCF-7 breast cancer cells using the [3(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] (MTT) assay. Their antiplasmodial efficacies were determined using Peter’s 4-day suppressive test against Plasmodium berghei in M. musculus while acute toxicities were investigated in the Mus musculus (mice). Ligand qualities were determined using ligand efficiency metrics, and molecular docking was conducted to determine the ligand interactions between ECC and the following enzymatic proteins, P. falciparum dihydroorotate dehydrogenase (PfDHOH) and P. falciparum purine nucleoside phosphorylase (PfPNP); and the molecular interaction between BDZ and PfDXR - Plasmodium falciparum 1-deoxy-D-xylulose-5-phosphate reductoisomerase, P. falciparum falcipain-2 and P. falciparum plasmepsin X (PfPMX). AHB showed no cytotoxicity against MCF-7 at (CC50) = 277.7 μM, while ECC showed inhibition with CC50= 3.930 μM, and BDZ showed no cytotoxicity CC50= 7373 μM. The in vitro antiplasmodial activity showed potency at (AHB)IC50 = 0.0020 ± 0.008 μM, (ECC) IC50= 0.0010 ± 0.002 μM, (BDZ) IC50= 0.0036 ± 0.003 μM respectively. BDZ showed the highest selectivity index at > 200,000, suggesting that it exhibited the best safety/efficacy among the three compounds. AHB displayed LD50 = >5000 mg/kg while ECC and BDZ displayed LD50 = 3162.28 mg/kg. Histopathological examinations showed non-toxicity by the three analogs on the liver and kidney of M. musculus. The percentage suppression of AHB (80.53 ± 3.26 %) at 400 mg/kg, was comparable to the standard chloroquine (81.71 ± 1.82 %) at 100 mg/kg where the mean survival time for both exceeded 30 days. ECC and BDZ showed excellent efficacies (70.98 ± 20.89 % and 83.66 ± 11.67 %) at 200 mg/kg, comparable to chloroquine 80.97 ± 5.82 %. The chemosuppression values for AHB and BDZ were significant at P value < 0.05. The ligand quality of ECC and BDZ displayed good Ligand Efficiency compared to chloroquine and artemisinin and higher enzyme affinities, and ligand efficiency dependent lipophilicity than the standard drugs. ECC and BDZ displayed good characteristics. The docking studies displayed strong hydrophobic interactions between ECC, PfDHODH, and PfPNP, suggesting good potency. BDZ’s binding with PfDXR, Pffalcipain-2, and PfPMX also displayed potency derived from hydrophobic and hydrogen interactions. Conclusively, this study showed AHB, ECC and BDZ were non-toxic to mammalian cells rodents’ liver and kidneys. These molecules exhibited good antiplasmodial inhibitory potential against both P. falciparum in vitro and P. berghei in vivo. ECC and BDZ displayed high ligand efficiency and strong molecular interactions with their protein targets. Therefore, all three analogs can be moved for further optimization in drug development.
Evaluation of Fire Safety Management Strategies in Selected Shopping Malls in Abuja, Nigeria
(F1000Research, 2025-04) Sholanke Anthony Babatunde; Dimuna K. O.; Olukayode B. G.
Background Incessant incidences have led to losses of several lives and huge investments in many developing countries, particularly Nigeria. This study evaluated fire safety management strategies of selected shopping malls in the city of Abuja, Nigeria in order to identify specific areas that require improvement. Methods The research adopted a case study approach and analysis of data through qualitative means. An observation guide designed for the study was used to collect data. The data were content analysed and the findings reported in themes with the aid of tables and photographs to enhance clarity and understanding. Results The result revealed that the efficacy of active fire safety strategies of the shopping malls exhibited various levels of inadequacies. Fire prevention devices such as sprinklers, smoke detectors and drenchers were either not provided or sparsely provided. The prevalent firemitigation devices found in the malls were fire extinguishers and fire buckets, which are grossly inadequate to prevent the rapid spread of large-scale fire. The passive fire safety measures of the malls also exhibited some levels of inadequacies. The study underscored the need for fire safety strategies in public buildings, particularly largescale commercial structures with high capacity of users, to be adequately provided and managed in adherence to standard practice and building code requirements. Conclusion The study recommends that building professionals should adapt innovative means to mitigate fire risk in the planning and development of commercial buildings. Also, making provisions to accommodate impulsive human behaviour during times of chaos should be a primary design consideration for building designers. The study emphasizes the need for further attention and improvement in fire safety management strategies implementation in commercial buildings, especially large-scale public facilities such as shopping malls, in order to appreciably guide against the devastating effect of fire in case of an occurrence.
AN OPTIMIZED DEEP-FOREST MODEL USING A MODIFIED DIFFERENTIAL EVOLUTION OPTIMIZATION ALGORITHM: A CASE OF HOST-PATHOGEN PROTEIN-PROTEIN INTERACTION PREDICTION
(Covenant University Ota, 2025-04) EMMANUEL JERRY DAUDA; Covenant University Thesis
Deep forest is an advanced ensemble learning technique that employs forest structures within a cascade framework, leveraging deep architectures to enhance predictive performance by adaptively capturing high-level feature representations. Despite its promise, deep forest models often face critical challenges, including manual hyperparameter optimization and inefficiencies in computational time and memory usage. To address these limitations, Bayesian optimization, a prominent model-based hyperparameter optimization method, is frequently utilized, with Differential Evolution (DE) serving as the acquisition function in recent implementations. However, DE's reliance on random index selection for constructing donor vectors introduces inefficiencies, as suboptimal or redundant indices may hinder the search for optimal solutions. This study introduces an optimized deep forest algorithm that integrates a modified DE acquisition function into Bayesian optimization to improve host-pathogen protein-protein interaction (HPPPI) prediction. The modified DE approach incorporates a weighted and adaptive donor vector selection mechanism, enhancing the exploration and exploitation of hyperparameter configurations. Performance evaluations using 10-fold cross-validation on human–Plasmodium falciparum (PF) protein sequence datasets sourced from reputable databases demonstrated the model's superiority over traditional Bayesian optimization, genetic algorithms, evolutionary strategies, and conventional machine learning models. The optimized framework achieved an accuracy of 89.3%, sensitivity of 85.4%, precision of 91.6%, and Area Under the Receiver Operating Characteristic Curve (AUROC) of 89.1%, surpassing existing methods. Additionally, the model exhibited reduced computational time and memory usage. The optimized DF was deployed as a web-based pipeline, DFH3PI (Deep Forest Host-Pathogen Protein-Protein Interaction Prediction), which successfully identified three potential human–PF PPIs previously classified as non-interacting: P50250–P08319, Q8ILI6–O94813, and Q7KQL3–Q96GQ7. These findings not only present the potential of DFH3PI for advancing HPPPI prediction but also establish the optimized deep forest framework as a transformative tool in computational biology. Its ability to combine accuracy and efficiency marks a significant step forward in predictive modeling.
ASSESSMENT OF HEALING ARCHITECTURE STRATEGIES FOR THE DESIGN OF ORIKI GROUP WELLNESS CENTRE, JABI, ABUJA, NIGERIA
(Covenant University Ota, 2025-06) INI-UKIM, Didarabasi Esther; Covenant University Dissertation
This study investigates the implementation of healing architecture strategies in the design of a wellness centre located in Jabi, Abuja, with a focus on enhancing users’ physical, emotional, and mental well-being. The study grounded in Biophilic Design Theory and Therapeutic Landscape Theory explores how nature-integrated and sensory design elements promote health and wellbeing. The research reviewed literature and relevant theoretical frameworks to reveal elements such as natural and artificial lighting, ventilation, biophilic elements, acoustic comfort, colour psychology and spatial coherence play crucial roles in a therapeutic environment to support physical and mental balance. A comparative analysis of international and domestic case studies to evaluate how these strategies have been implemented in existing wellness centres around the world including SHA Wellness Clinic, Chiva-Som, Mii Amo and Abuja based centres such as Nisa Wellness Retreat, Beauty Secrets MedSpa, and JVee Wellness Spa. Findings from the analysis showed Nisa Wellness Retreat and Beauty Secrets MedSpa demonstrated stronger biophilic and therapeutic elements compared to JVee Wellness Spa. Structured questionnaires were administered to assess user perception of these healing architecture strategies, and the responses were analysed using descriptive statistics and reliability tests (Cronbach’s Alpha = 0.856). The results indicate users highly value natural lighting, quietness, ventilation and exposure to nature, as these strategies contribute significantly to relaxation, mental clarity and overall comfort. The research offers valuable design insights for architects and developers seeking to incorporate healing architecture strategies therapeutic environments.
ASSESSMENT OF PEDESTRIAN CIRCULATION STRATEGIES IN THE DESIGN OF HIGH-SPEED TRAIN TERMINAL, IJOKO, NIGERIA
(Covenant University Ota, 2025-07) Nzeh Millicent Eberechukwu; Covenant University Dissertation
Urban public transportation availability, which has tremendous potential to replace private vehicle use, is a dire need in the 21st Century. This is because of the continuous increase in global urbanisation. The heartbeat of transit systems within large cities is train terminals, which have gained prominence since the Industrial Era. However, minute consideration has been given to the planning of pedestrian circulation and the unique requirements of passengers within train terminals, posing a threat to the safety and efficiency of these transportation systems. Therefore, the aim of this study is to evaluate pedestrian circulation in existing train terminals with a view to implementing strategies that enhance user experience in the design of a high-speed train terminal in Ijoko, Ogun. A mixed-method approach is adopted as the research approach, involving the qualitative and quantitative aspects. The qualitative aspect involved examining and obtaining data from three selected Nigerian train terminals and four foreign train terminals used as the case studies. Conversely, quantitative data were harnessed by a questionnaire from fifty-five users of train stations. For a comprehensive analysis of the quantitative data, version 27 of the Statistical Package for the Social Sciences (SPSS) software was used. Tables, figures and plates were utilised to present the research results effectively. The mean ranking of the implemented pedestrian circulation strategies within the three local case studies was computed using SPSS. Similarly, the pedestrian circulation strategies’ portion of variance and sphericity of correlation matrix were also thoroughly computed through the Kaiser-Meyer-Olkin’s (KMO) and Bartlett’s tests, respectively. The appropriate size and positioning of vertical circulation and horizontal circulation systems, as well as the availability of signage showing the building’s functional spaces, are some of the pertinent pedestrian circulation strategies that influence satisfaction with the overall user experience in train terminals. This research study deeply explores important considerations for optimal pedestrian circulation through the proposal of an architectural design of a high-speed train terminal in Ogun State, Nigeria. The findings will be useful to built industry professionals involved in the design of high-speed train terminals. Three of the Sustainable Development Goals (SDGs) are advocated for in this study, which are the ninth goal of “industry, innovation, and infrastructure”; the eleventh goal of “sustainable cities and communities”; and the third goal of “good health and well-being”
EVALUATION OF ACOUSTIC STRATEGIES FOR THE DESIGN OF CHRIST EMBASSY YOUTH CHURCH, IKEJA LAGOS, NIGERIA
(Covenant University Ota, 2025-07) Agbateyiniro, Dede Emmanuela; Covenant University Dissertation
EVALUATION OF ENERGY EFFICIENCY STRATEGIES FOR THE DESIGN OF GUILDANCE COMMUNITY DEVELOPMENT FOUNDATION COMMUNITY CENTER, AGO, LAGOS, NIGERIA
(Covenant University Ota, 2025-07) Demide, Eneji Alikali; Covenant University Dissertation
This study investigates the deployment of design strategies that enhance energy efficiency in designing community centers in Lagos, Nigeria, highlighting the critical need for sustainable practices in urban infrastructure. As Nigeria grapples with rapid urbanization and energy challenges, community centers are vital hubs for social interaction and service delivery. However, many facilities operate inefficiently due to outdated infrastructure and a lack of integration of modern energy-saving technologies. This research aims to identify effective energy-efficient strategies tailored to the unique context of Lagos while examining the barriers to their implementation. Through qualitative interviews with key stakeholders and quantitative assessments of energy consumption patterns, this study evaluates the impacts of energy inefficiency on operational costs and environmental performance. The findings underscore the importance of adopting innovative solutions, such as solar power systems and passive cooling techniques, to enhance sustainability and reduce operational costs. Addressing the existing knowledge gaps and providing targeted recommendations, this research contributes to advancing sustainable urban development practices in Nigeria, ultimately fostering improved quality of life for residents.
EVALUATION OF SALUTOGENIC STRATEGIES AND WORKERS’ SENSE OF COHERENCE FOR THE DESIGN OF EKULO BEVERAGE FACTORY, MAKURDI, NIGERIA
(Covenant University Ota, 2025-07) Apav, Fabian Demenongo; Covenant University Dissertation
In an era where employee well-being is increasingly linked to organisational success, factory environments must evolve beyond mere efficiency. Beverage factories, often characterised by repetitive tasks, noise, and physical strain, rarely consider the psychological and emotional needs of their workers. This study investigates how salutogenic design, an approach focused on promoting health rather than simply preventing illness, can enhance the Sense of Coherence (SOC) among workers in beverage factories in Benue State, Nigeria. Salutogenesis, a concept developed by Aaron Antonovsky, centres on three pillars of SOC: comprehensibility, manageability, and meaningfulness. When embedded into workplace architecture, these principles can mitigate stress, improve job satisfaction, and enhance productivity. Despite global research highlighting the benefits of salutogenic environments in healthcare and education, their integration into industrial settings remains sparse. The aim of this study was to evaluate the impact of salutogenic design on worker well-being and to propose a factory design model that strengthens SOC. Using a mixed-methods approach including observations of salutogenic elements and sharing of questionnaires across selected beverage factories, the research assessed the presence of key design elements: natural light and ventilation, noise control, and restorative spaces. Findings revealed that most factories underprioritised these elements, resulting in low SOC ratings among workers. Further analysis such as regression analysis established a positive correlation between salutogenic environments and higher SOC scores. The study culminates in a design proposal for a beverage factory that integrates salutogenic principles to foster a healthier, more productive workforce. The results advocate for a shift in industrial design philosophy where human-centered spaces are not luxuries but necessities. By aligning with Sustainable Development Goals (3, 8, and 9), this research contributes to both academic discourse and practical applications in industrial architecture.
EVALUATION OF SALUTOGENIC STRATEGIES AND WORKERS’ SENSE OF COHERENCE FOR THE DESIGN OF EKULO BEVERAGE FACTORY, MAKURDI, NIGERIA
(Covenant University Ota, 2025-07) Apav, Fabian Demenongo; Covenant University Dissertation
In an era where employee well-being is increasingly linked to organisational success, factory environments must evolve beyond mere efficiency. Beverage factories, often characterised by repetitive tasks, noise, and physical strain, rarely consider the psychological and emotional needs of their workers. This study investigates how salutogenic design, an approach focused on promoting health rather than simply preventing illness, can enhance the Sense of Coherence (SOC) among workers in beverage factories in Benue State, Nigeria. Salutogenesis, a concept developed by Aaron Antonovsky, centres on three pillars of SOC: comprehensibility, manageability, and meaningfulness. When embedded into workplace architecture, these principles can mitigate stress, improve job satisfaction, and enhance productivity. Despite global research highlighting the benefits of salutogenic environments in healthcare and education, their integration into industrial settings remains sparse. The aim of this study was to evaluate the impact of salutogenic design on worker well-being and to propose a factory design model that strengthens SOC. Using a mixed-methods approach including observations of salutogenic elements and sharing of questionnaires across selected beverage factories, the research assessed the presence of key design elements: natural light and ventilation, noise control, and restorative spaces. Findings revealed that most factories underprioritised these elements, resulting in low SOC ratings among workers. Further analysis such as regression analysis established a positive correlation between salutogenic environments and higher SOC scores. The study culminates in a design proposal for a beverage factory that integrates salutogenic principles to foster a healthier, more productive workforce. The results advocate for a shift in industrial design philosophy where human-centered spaces are not luxuries but necessities. By aligning with Sustainable Development Goals (3, 8, and 9), this research contributes to both academic discourse and practical applications in industrial architecture.