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Item Anti-Aging Potential of Bioactive Phytoconstituents Found in Edible Medicinal Plants: A Review(MDPI, 2024-06) Iweala, Emeka J.; Adurosakin, Oluwapelumi Eniola; Innocent, Ugochukwu; Omonhinmin, Conrad A.; Dania, Omoremime Elizabeth; Ugbogu, Eziuche A.Aging is a complex biological and physiological change that leads to a loss of function in all living organisms. Although the mechanism behind the aging process is still largely unknown, scientific studies have shown that oxidative stress and age-related low autophagy, which are associated with various chronic diseases such as cancer, diabetes, cardiovascular diseases, and neurodegenerative diseases, promote aging. Interestingly, many medicinal plants and their biologically active compounds have the ability to extend lifespan as they can inhibit oxidative stress and promote autophagy. This review evaluates and provides up-to-date information on the anti-aging potential of bioactive compounds in edible medicinal plants. In this study, seventeen (17) biologically active compounds from edible medicinal plants with anti-aging effects were reviewed. In vivo and in vitro studies showed that these biologically active compounds exhibit anti-aging effects via various mechanisms such as the activation of autophagy, increases in antioxidant enzymes, reductions in reactive oxygen species, the inhibition of inflammatory markers, and the downregulation of senescence genes. This study suggests that edible medicinal plants containing these bioactive compounds may promote health and extend lifespan. However, the exact mechanisms, effective doses, clinical trials, and chronic and genotoxic effects of bioactive compounds as anti-aging agents should be further investigated.Item Bioactive Phytoconstituents and Their Therapeutic Potentials in the Treatment of Haematological Cancers: A Review(MDPI, 2023-02) Iweala, Emeka J.; Oluwapelum, Adurosakin E.; Dania, Omoremime Elizabeth; Ugbogu, Eziuche A.Haematological (blood) cancers are the cancers of the blood and lymphoid forming tissues which represents approximately 10% of all cancers. It has been reported that approximately 60% of all blood cancers are incurable. Despite substantial improvement in access to detection/diagnosis, chemotherapy and bone marrow transplantation, there is still high recurrence and unpredictable but clearly defined relapses indicating that effective therapies are still lacking. Over the past two decades, medicinal plants and their biologically active compounds are being used as potential remedies and alternative therapies for the treatment of cancer. This is due to their anti-oxidant, anti-inflammatory, anti-mutagenic, anti-angiogenic, anti-cancer activities and negligible side effects. These bioactive compounds have the capacity to reduce proliferation of haematological cancers via various mechanisms such as promoting apoptosis, transcription regulation, inhibition of signalling pathways, downregulating receptors and blocking cell cycle. This review study highlights the mechanistic and beneficial effects of nine bioactive compounds (quercetin, ursolic acid, fisetin, resveratrol, epigallocatechin gallate, curcumin, gambogic acid, butein and celastrol) as potential remedies for chemoprevention of haematological cancers. The study provides useful insights on the effectiveness of the use of bioactive compounds from plants for chemoprevention of haematological cancers.Item Determination Of Nutritional Potential Of Cymbopogon Citratus (D.C.) Staph By Atomic Absorption Spectroscopy And Its Health Benefits(International Journal of Innovative Research and Advanced Studies (IJIRAS) Volume 5 Issue 3,, 2018) Umoh, Emmanuel Michael; Sam, Edidiong Sunday; Udoh, I. I.Lemon grass (Cymbopogon citratus) was processed for analyses. They were sorted and chopped into bits. They were sundried for 12hrs, oven dried for 24hrs at 60oC and pulverized. Digestion was carried out according to AOAC 2000 and analysed for P, Mg, K, Na, Se, B, Co, Fe, Zn, Mn, Cu and Ca contents using Unicam 939/959 Atomic Absorption Spectrophotometer. Out of these twelve “botanical based minerals”, the most abundant was potassium followed by magnesium, phosphorus and calcium the least being boron. Most nutritional problems in Nigeria experienced by the vulnerable groups - the children and the elderly are due to mineral deficiencies in unwholesome or processed foods. Minerals usually obtained from synthetic mineral supplements are inadequate for the rural population due to high cost of procurement and at times adulteration. Most of them are toxic to susceptible individuals. Lemon grass is very effective in „Ajurvedic‟ medicine because of the “botanical based minerals” and bioactive compounds therefore taken in adequate quantities will help in the improvement of general health.