The interplay of post-translational modification and gene therapy
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Several proteins interact either to activate or repress the expression of other genes
during transcription. Based on the impact of these activities, the proteins can be classified into
readers, modifier writers, and modifier erasers depending on whether histone marks are read,
added, or removed, respectively, from a specific amino acid. Transcription is controlled by
dynamic epigenetic marks with serious health implications in certain complex diseases, whose
understanding may be useful in gene therapy. This work highlights traditional and current
advances in post-translational modifications with relevance to gene therapy delivery. We report
that enhanced understanding of epigenetic machinery provides clues to functional implication
of certain genes/gene products and may facilitate transition toward revision of our clinical
treatment procedure with effective fortification of gene therapy delivery
Keywords
Q Science (General), QA75 Electronic computers. Computer science