Potassium Dichromate-Induced Hepato- and Hematotoxicity in Rats: Nutritive Composition and Ameliorative Role of Acacia nilotica L. Leaf
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Background: Chromium and its salts, as well as chromium-containing compounds, play a major role in numerous manufacturing
processes and have been contraindicated in carcinogenic, toxic, and mutagenic conditions in people involved in these processes.
Objectives: This study investigated the ameliorative role of Acacia nilotica aqueous leave extract (ANLA) on potassium dichromateinduced
liver and blood toxicity in male and female rats. Phytochemical screening and nutrient composition of ANLA were also
evaluated.
Methods: Phytochemical and proximate analysis of ANLA were carried out. Twenty adult male and female rats each were divided
into four groups (n = 10): (1) control; (2) potassium dichromate (PDC; 0.625 mg/kg body weight); (3) PDC co-treated with ANLA after
seven days (650mg/kgbwt); and(4)PDCco-treated withANLA(650mg/kgbwt) simultaneously for 21 days. Biomarkers of liver injury,
lipid, and hematological imbalance were assessed. Tissue histology and toxicant retention were done.
Results: Various plant secondary metabolites (flavonoids, terpenoids, tannins, phenols, saponins, cardiac glycosides, alkaloids, and
anthraquinones) and nutrients (protein = 67.41 � 2.44%; carbohydrate = 9.87 � 1.87%; fiber = 10.01 � 1.21%; mineral = 6.41 � 1.08%;
fat and oil = 6.63 � 0.93%) were identified in the leave. Exposure to chromium significantly (P < 0.05) increased plasma alanine
aminotransferase (ALT) and aspartate aminotransferase (AST) with a concomitant decrease in the activity of these enzymes in the
liver of both male and female rats. The exposure also altered protein, triglyceride, and cholesterol levels in the plasma and liver as
well as hematological indices. Organ chromium retention and pathological changes were also observed. ANLA modulated these
chromium-induced alterations in the rats.
Conclusions: Based on the results, ANLA possesses ameliorative property against PDC-induced toxicity in rats. Thus it may be used
to combat chromium poisoning. The nutritive potential of A. nilotica leaves may also be maximized.
Keywords
QH Natural history, QH301 Biology