A ReviewofNovelCancerTherapeuticsandCurrent Research Trends
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Date
2025
Journal Title
Journal ISSN
Volume Title
Publisher
Wiley The Scientific World Journal Volume 2025
Abstract
The uncheckedgrowthandspreadofaberrantcellsdescribeawidelydiversecollectionofdisordersthatcollectivelyconstitute
cancer. Conventionaltherapiesforcancer,includingradiationtherapy,chemotherapy,andsurgery,haveincreasedthechances
of survivalsignificantly inmostpatients.Thesetraditionalmethodsusuallyresultinlowtumorortumorcellspecificity,
significant systemictoxicity,andthedevelopmentofdrugresistance.Thisreviewsummarizesupdatesincancertherapy,some
of whichincludecutting-edgetherapiesrepresentedbyCAR-Ttherapy,targetedtherapies,genetherapy,arginine-depriving
therapy, mitochondria-targetedtherapies,neutrophil-targetedtherapies,andthelatestPROTACtechnologyforproteolysis-
targeting chimera.Ithasemphasizedmechanismsunderlyingthesenewtherapeuticstrategiesandtheirtranslationalpotential
for treatinghumancancers.Wefurtherdiscuss,foreachapproach,thechallenges,limitations,sideeffects, anddelivery
systems. Thereviewproceedswithadynamicchangeinthelandscapeofcancerresearchinbiology,wheremachinelearning
and artificial intelligenceareincreasinglyimportanttoimproveourunderstandingofthemechanismsofcancerandtreatment
responses. Wealsodescribethepotentialofstemcelltherapy,metabolomics,andnoveldrugdeliverysystemstowardbetter
patient outcomes.Thepaperpullstogethersomeofthecurrentresearch findings andresultsofclinicaltrialsinnew
therapeutic developmentsandemergingareasofresearchthatholdoutexcitingpromisesforthefutureprogressofcancer
treatment
Description
Keywords
cancer biology, cancertherapeutics, CAR-T, emergingtherapies, genetherapy, PROTAC