A ReviewofNovelCancerTherapeuticsandCurrent Research Trends

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dc.contributor.authorOluwajembola, Abimbola Mary
dc.contributor.authorZakari, Suleiman
dc.contributor.authorCleanclay, Wisdom D.
dc.contributor.authorAyeni, Timothy
dc.contributor.authorAdebosoye, Adewale
dc.contributor.authorOkoh, Olayinka S.
dc.contributor.authorFolamade, Joshua
dc.contributor.authorBawa, Inalegwu
dc.contributor.authorOgunlana, OlubankeOlujoke
dc.date.accessioned2026-02-18T15:31:57Z
dc.date.issued2025
dc.description.abstractThe uncheckedgrowthandspreadofaberrantcellsdescribeawidelydiversecollectionofdisordersthatcollectivelyconstitute cancer. Conventionaltherapiesforcancer,includingradiationtherapy,chemotherapy,andsurgery,haveincreasedthechances of survivalsignificantly inmostpatients.Thesetraditionalmethodsusuallyresultinlowtumorortumorcellspecificity, significant systemictoxicity,andthedevelopmentofdrugresistance.Thisreviewsummarizesupdatesincancertherapy,some of whichincludecutting-edgetherapiesrepresentedbyCAR-Ttherapy,targetedtherapies,genetherapy,arginine-depriving therapy, mitochondria-targetedtherapies,neutrophil-targetedtherapies,andthelatestPROTACtechnologyforproteolysis- targeting chimera.Ithasemphasizedmechanismsunderlyingthesenewtherapeuticstrategiesandtheirtranslationalpotential for treatinghumancancers.Wefurtherdiscuss,foreachapproach,thechallenges,limitations,sideeffects, anddelivery systems. Thereviewproceedswithadynamicchangeinthelandscapeofcancerresearchinbiology,wheremachinelearning and artificial intelligenceareincreasinglyimportanttoimproveourunderstandingofthemechanismsofcancerandtreatment responses. Wealsodescribethepotentialofstemcelltherapy,metabolomics,andnoveldrugdeliverysystemstowardbetter patient outcomes.Thepaperpullstogethersomeofthecurrentresearch findings andresultsofclinicaltrialsinnew therapeutic developmentsandemergingareasofresearchthatholdoutexcitingpromisesforthefutureprogressofcancer treatment
dc.identifier.issnhttps://doi.org/10.1155/tswj/5056618
dc.identifier.urihttps://repository.covenantuniversity.edu.ng/handle/123456789/50620
dc.language.isoen
dc.publisherWiley The Scientific World Journal Volume 2025
dc.subjectcancer biology
dc.subjectcancertherapeutics
dc.subjectCAR-T
dc.subjectemergingtherapies
dc.subjectgenetherapy
dc.subjectPROTAC
dc.titleA ReviewofNovelCancerTherapeuticsandCurrent Research Trends
dc.typeArticle

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Programme: BIochemistry