Antioxidant and DPPH-Scavenging Activities of Compounds and Ethanolic Extract of the Leaf and Twigs of Caesalpinia bonduc L. Roxb.
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Description
Antioxidant effects of ethanolic extract of Caesalpinia bonduc and its isolated bioactive
compounds were evaluated in vitro. The compounds included two new cassane
diterpenes, 1α,7α-diacetoxy-5α,6β-dihydroxyl-cass-14(15)-epoxy-16,12-olide (1)
and 12α-ethoxyl-1α,14β-diacetoxy-2α,5α-dihydroxyl-cass-13(15)-en-16,12-olide
(2); and others, bonducellin (3), 7,4’-dihydroxy-3,11-dehydrohomoisoflavanone blocking the expression of SREBP-1c and FAS through LKB1/SIRT1 and AMPK
activation in HepG2 cells, suggesting that CDCQ is a novel AMPK activator with
a potential role in the prevention obesity.
Keywords
QD Chemistry, QH301 Biology