Facile Synthesis and Characterization of Substituted Pyrimidin-2(1.H)-ones and their Chalcone Precursors
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Abstract
Description
A new and efficient method has been developed for the quantitative transformation of chalcon.es
to pyrimidine frame work via solid support catalysis. Silica supported sulphuric acid (SSA) efficiently
catalyzed the reaction of a-[3-unsaturated carbonyl, chalcones (1-10) with urea to afford substituted
pyrimidin-2(1H)-ones (11-20) in good to excellent yield. The interesting behaviour of SSA lies in the fact
that it can be re-used after simple washing with chloroform thereby rendering this procedure more
economical. The chemical structures were confrrmed by analytical data as well as spectroscopic means
Keywords
Q Science (General), QD Chemistry